What is the most effective Pernicious Anemia treatment? In two words: B12 injections. It is the only effective way for PA patients to absorb B12, since it bypasses the gastric system and goes straight to your bloodstream.
The scandal is that despite it being so simple, inexpensive and harmless, many patients end up with permanent damage because they are unable to get it.
This is why we created this resource.
Even in educated countries like the US or the UK, the health system constantly deny access from Pernicious Anemia patients to the B12 shots that they so badly need to save their lives. Most B12 deficiency and Pernicious Anemia patients in the UK get only four injections a year, that is, if they’re fortunate enough to be diagnosed correctly. Four injections a year is a joke, and is more about saving healthcare money than taking good care of patients. Go ask your doctor for evidence that one injection every three months is enough. He won’t find any. There is no evidence whatsoever for this frequency to be effective. Your doctor should treat you at least according to the NICE and BNF guidelines, both state that you have to be on every-other-day injections until your symptoms stop improving. Most Pernicious Anemia patients will have to remain on B12 treatment for life, since their bodies can’t otherwise absorb this crucial vitamin.
More than a century ago, people with Pernicious Anemia would eventually die of the disease. Liver extract injections became available and used to be the treatment until vitamin B12 injections were available.
Can I treat Pernicious Anemia with oral B12 supplementation?
No. According to the British Committee for Standards in Haematology:
There are arguments against the use of oral cobalamin in initiation of cobalamin therapy in severely deficient individuals who have poor absorption, especially due to pernicious anaemia.
Frequency of B12 Injections for Pernicious Anemia Treatment?
In the UK, doctors normally prescribe one injection every three months. This is nothing short of a scandal. In the 60’s, patients had an injection once a month, then it was increased to once every two months in the 70’s, and in the 80’s to every three months, which is the frequency often used today.
None of the above is enough.
We recommend small and frequent doses, daily at least for people who show severe symptoms (especially neurological). Of course, getting your doctors to give you daily shots isn’t easy, in which case you’ll have to find an alternative source. This is why we’re here 😉
Why is Pernicious Anemia Treated With Injections of B12?
Pernicious Anemia B12 Injections Not Working For Me!
Best Pernicious Anemia Treatment: Cyanocobalamin, Methylcobalamin, Hydroxycobalamin or Adenosylcobalamin?
And those are inactive hydroxocobalamin that the body needs to activate to one of the active forms (methylcobalamin and adenosylcobalamin).
Millions of people around the world are B12 deficient. In the UK alone, hundreds of thousands of citizens are routinely misdiagnosed and continue to deteriorate without proper treatment. It’s all very tragic, and we think B12 injections should be administered almost by default. It is a water soluble vitamin — any excess is flushed out in the urine — so there’s no possibility of toxicity, and you can’t overdose. Where’s the risk? It is even used in enormous concentrations to treat cyanide poisoning.
Pernicious Anemia is called pernicious (deadly!) for a reason. It used to be lethal, until doctors found a way to get B12 to the bloodstream. When you lack B12, Myelin start to strip away. Myelin is a protective layer coating your nerves, and all kinds of neurological symptoms begin to appear. Unfortunately damage to the myelin is often permanent, so action must be taken immediately and treatment should never be delayed.
The tragedy is that doctors aren’t looking for B12 and patients end up misdiagnosed with other conditions such as Alzheimer, Parkinson, MS, Chronic Fatigue Syndrome, Bipolar disorder, Autism, Fibromyalgia, and others. The diagnostic tests are often flawed, and there’s an enraging lack of knowledge among professionals.
Having injectable B12 ready over the counter will make Pernicious Anemia treatment a thousand fold easier, and will have a profound effect on the lives of patients, their families, and our society. Many doctors are treating B12-induced depression with antidepressants, while it can disappear entirely by regular administration of something as simple as B12. It’s not toxic, it repairs nerves, and it is very inexpensive. It beggars belief! Like diabetic patients, every PA sufferer needs to be able to buy OTC and self-inject this life saving vitamin.
In Germany, France, and Spain you can buy B12 injections over the counter in any pharmacy. In Japan and Malaysia, you can even buy them in supermarkets!
We created this site to educate people about the lethal, subtle nature of Pernicious Anemia, and to give patients a chance for optimal treatment by giving them access to as many B12 shots as they need. Your plea for help will no longer fall on deaf ears. Each person has a different level of damage, and some symptoms are reversible when caught and treated early. Don’t wait a second longer. The Pernicious Anemia Society found that almost two-thirds of patients were unpleased with their current treatment, and 14% of patients waited more than ten years for correct treatment!
Because of the complete and unbelievable restriction from getting enough B12 from doctors, Patients used to turn to online pharmacies to buy B12 shots. Unfortunately, recent regulations have made injectable vitamins nearly impossible to find online. This is why gave rise to this website.
Many doctors are simply unable to comprehend the debilitating and deadly nature of something as simple as B12 deficiency. And when you can’t absorb B12 from the stomach, your life is seriously at risk if you don’t take frequent B12 injections. While patients get them once every three months, B12 deficient dogs are given weekly ones! It’s unbelievable. How are you expected to survive for three months on a single injection? It’s a water soluble vitamin, remember, and the body retains only so much of it. It needs frequent replenishment. Some doctors give their patients oral B12 tablets to handle their neurological Pernicious Anemia symptoms, which is crazy to us. Only — and only — injections should be given, and frequently.
As current things are, Pernicious Anemia patients are at the mercy of an outdated, restrictive and uneducated system, providing ridiculous treatment and leaving behind a trail of severe suffering.
Some of our doctors who do understand B12 deficiency and pernicious anaemia are reprimanded for prescribing B12 injections for desperately ill symptomatic patients who are ‘within range’ on flawed B12 serum tests.
This under treatment renders those of us with this condition – amongst other things – seriously mentally impaired, experiencing debilitating pain, bed ridden, chronically fatigued, at high risk of stroke or heart attack, and unable to walk or to stay awake. (It’s your time to live, not merely exist.)
Some patients have successfully fought for the right to receive more frequent injections however most of us are denied this luxury. Most don’t succeed in educating their doctors and many don’t have the energy to fight, so continue to deteriorate steadily.
Pernicious Anemia Treatment Guidelines
First of all, don’t wait. The new British Committee for Standards in Haematology guidelines state clearly that the clinical symptoms are what’s important. Similarly, the United Kingdom National Quality Assessment Scheme for Haematinic Assays (UK NEQAS) warn against false normal B12 results and the risk of neurological damage:
In the event of any discordance between clinical findings of B12 deficiency and a normal B12 laboratory result, then treatment should not be delayed. Clinical findings might include possible pernicious anaemia or neuropathy including subacute combined degeneration of the cord. We recommend storing serum for further analysis including MMA, or holotranscobalamin and intrinsic factor antibody analysis, and treating the patient immediately with parenteral B12 treatment.
So, if you have Pernicious Anemia symptoms — even if results look okay — begin to treat immediately.
We believe B12 shots — methylcobalamin, not cheap cyanocobalamin — should be sold over the counter in every country. Treating Pernicious Anemia, when that day comes, will be much easier for everyone.
How to Treat Pernicious Anemia?
There’s no Pernicious Anemia medication drugs. There are only B12 injections, which are simply a nutritional supplement delivered straight to the bloodstream.
How to Treat Pernicious Anemia Naturally? If you’re looking for a natural Pernicious Anemia Treatment, you’ll have to redefine what you consider natural.
As for skin patches, nasal spray, or sublingual tablets, those are risky. Some people report positive results, but those with a true Pernicious Anemia are unlikely to get any benefit from them. When you take an oral B12 supplement as a Pernicious Anemia patient, you are essentially hoping some of the B12 will make its way into your bloodstream without the aid of Intrinsic Factor. Why take that chance?
Where to Get B12 Injections?
If your doctor refuses to prescribe frequent injections, you have a few choices. Go to a private doctor. This can get expensive, from $50 to 250 per injection. Most people can’t afford this. There’s also no reason to. For that price you can get a vial of B12 that’ll give you 30 injections. Another option is to find an infusion clinic, where you’ll receive methylcobalamin dripping intravenously, saturating your cell receptors with B12. Those cost anywhere from $100 to $500 per visit.
Over the counter at pharmacies.
In some countries you can buy injectable B12 over the counter in pharmacies. Germany, France, Spain, Australia, New Zealand are good examples. In Japan and Malaysia you can even buy injections at supermarkets!
Over the internet.
Careful with this one. Many online providers sell unlicensed B12, with no documents to back it up. We’ve even seen Chinese B12 injections bought from AliExpress and sold online to the public!
This is risky and not recommended. There used to be a few internet providers of B12 shots, American companies, but recent regulations in the USA made injectable vitamins almost impossible to buy online. You now have to get a prescription, pay for a consultation call (~$50) and that’s only if their doctor is in the state where you’re from.
Pernicious Anemia Treatment Side Effects
There is a big misunderstanding among health practitioners, who under-treat their patients with infrequent doses that are way below what the patient actually needs. They sometimes stop treatment altogether! This results in many patients being left with recurring symptoms that may get permanent!
After each injection, serum B12 levels rise in the blood, way above the upper recommended value (~150-700 pmol/L normally), followed by a slow and gradual decrease. Many health professionals think it’s needed to to keep levels between that range, but it’s not. B12 levels in the blood rise regardless of therapeutic effectiveness. Let me state clearly:
High blood levels of B12 do not mean symptoms are well treated. That is especially important for people with neurological symptoms, which can easily become permanent if left untreated for enough time.
This is because of an imaginary fear of overdosing, but extremely high-dose vitamin B12 treatment has actually been used without issues for more than a half a century.
There are no side effects to vitamin B12. It is the safest thing you can inject into your body, and has been used for a long time — in massive amounts — to treat cyanide poisoning and the like. In life threatening cases, 5,000,000mcg (!!!) of hydroxocobalamin is given directly to the veins within 15 minutes. That is about 5,000 injections dosage all at once! Blood levels of B12 quickly rise to 560,000,000pmol/L, and if necessary the treatment is repeated within hours, for a total of 10,000,000mcg of B12. Side effects are harmless and temporary, like the skin and urine becoming reddish. As you see, B12 is so safe even 10,000 injections a day can’t make you overdose.
Treatment with high dose vitamin B12 has been shown to be completely safe for more than sixty years! Let’s take a look:
When treating children with an inborn error in production of transcobalamin II (the binding protein that transports B12 to the cells), blood levels of ~7500pmol/L show zero side effects.
In Japan, patients with Multiple Sclerosis who received daily tablets of 60,000mcg of methylcobalamin for half a year showed no side effects and no toxicity. Half of them even started with two weeks of daily 5,000mcg B12 shots straight to the bloodstream. Also in Japan, kidney dialysis patients received doses of methylcobalamin so high their blood levels rose from an average of 422pmol/L to 54,000pmol/L (with 67,000 being the highest value) without side effects. That’s a hundred times the recommended range 😉
And… another one from Japan (leading researchers on B12): Patients with ALS received methylcobalamin shots of 25,000-50,000mcg (!!!), at first daily and then twice a week. The ALS progressed slower on those patients and they survived much longer than untreated patients.
Here’s an interesting one:
Back then in the 50’s, before chemotherapy was available, children with a neuroblastoma tumor received massive doses of B12 injections every two days, for 2-3 years, with great success.
Unfortunately, out of an unfounded fear of overdosing, treatment is often reduced far below the necessary frequency, especially for a Pernicious Anemia patient. B12 is water soluble, any excess is flushed out in the urine, so it is completely harmless. Under-treating makes symptoms reappear very quickly in-between injection sessions, and cause some of them to become permanent. This misunderstanding is nothing less than a tragedy.
Vitamin B12 is non-toxic, even in humongous amounts.
Ever since vitamin B12 was isolated as a substance, it has been used in extremely high doses for a variety of treatments. In all that time, not even a single harmful case has been found in medical literature.
There’s only one caveat:
Before receiving your first injection, you may want to be supervised by a qualified medical professional. In very rare cases, the patient may develop an anaphylactic shock to the injection. It rarely happens, but keep that in mind. It is my suspicion that people get an allergic response not to the B12 itself, but to additives many injection brands add to their products. Try to find something pure.
What is the treatment for Pernicious Anemia?
In most places, the regular Pernicious Anemia treatment includes an hydroxycobalamin B12 injection every two or three months, following an initial loading phase of 5-10 injections within a couple of weeks. Perhaps the reason why patients are being treated with one injection every few months is that after the initial doses, this is enough to keep their serum blood levels in the desired range. But again, blood levels mean little.
Pernicious Anemia treatment with very high-dose B12 injections is not only very safe but also very effective. Starting straight away, some patients may recover completely. It is important to keep supplementing for life. B12 shots give new life to patients who would otherwise live in a nightmare.
Change The Diet During Pernicious Anemia Treatment?
When you’re going from severe anemia to normal production of red blood cells during your B12 injection therapy, levels of potassium could drop, and high platelet counts in the blood could occur. Monitoring both those levels is recommended. You may want to have a Pernicious Anemia diet plan rich in potassium rich foods – like dark leafy greens (spinach, kale, etc), baked sweet potato with the skin on, salmon, avocado, and bananas. Careful with the carbs if you’re diabetic. Also, don’t forget that B12 and folate need each other to perform. If you’re not at the upper end of folate, we recommend supplementing. Folic acid isn’t very effective, we like the l-methylfolate form a lot more.
Please share this resource so that we can drive a complete overhaul in the treatment of Pernicious Anemia (and B12 deficiency generally). Imagine if diabetic patients could only inject once every three months? No sane country should give their patients four injections a year only. It is madness to think that humans only need this crucial, water-soluble vitamin (which is more easily flushed out than stored) four times a year. They do it to save money, but they are not fully aware of the devastating effects of an untreated B12 deficiency and Pernicious Anemia. Those untreated patients end up costing a lot more to the country to look after. The obsession with blood values should stop, it doesn’t mean much! Instead, health practitioners should listen to their patients and treat based on symptoms alone.