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Regev.
Is it possible to inject sufficient Methylcobalamine to last 1 month instead of once a day? Also, in the past I have found the pharmacies in US all want a Rx for syringes, making it necessary to get an RX for syringes and for injectable saline. That adds cost to your price for Methylcobalamine, if I can even find a Dr to Rx it. I am in the US and it doesnt seem that there has been as much research here as in your country. I have been looking off and on for 40 years for a healthcare practitioner here that is interested in looking at alternative Cobalamin, but they all seem to say Cyanocobalamin and there is nothing else. So I alternate between giving up & new searches as I get weird symptoms of PA off & on even though my blood test says I have enough B12, but my blood cell count fors not show that. So now because Im 71 they say any symptoms are typical of my age without realizing I have had PA & taking Cyanocobalamin since I was 31!
Altogether very frustrating.
Thank you!
Jeanne – You can buy syringes and saline very cheap on Amazon. No RX. Remember that Western med doctors have very little knowledge on how to treat PA. That’s why this site is so important. You have to do your own research and unfortunately, treat yourself.
My wife ( P.A. for six years.) has two- monthly injections at her surgery given by her nurse, and more often than not she still has terrible bouts of extreme fatigue, disorientation, crying, and feels she can no longer go on. She endures much mental and physical anguish and I would appreciate any advice on how one can improve her quality of life.
Exceedingly concerned husband. TOM.😥😰
I need to know what kind of saline to purchase for mixing the b12 powder. There are different percentages of sodium chloride out there.
Hello and thank you so much. I recently requested a B 12 test after seeing specialist after specialist after specialist and all my test coming back normal B 12 however was 180. My hematologist is recommending 1000 mg be 12 injections one time a week for a month and then retest does this sound like a good plan to you? I’m also wondering if you can tell me how B12 affect sleep because I’ve been having a really difficult time sleeping as well and I’ve heard that it has to do with how B12 supports the melatonin process?
I developed a very severe form of anemia after being a vegan for four and a half years, and had absolutely no energy for anything. After supplementing myself for a few months – i am feelin so so so much better! consider injecting b12 and don’t neglect your health.
Your B12 came today, I can’t wait to try it! I have chronic fatigue and been getting vitamin B12 shots at the chiropractor, but they charge a ridiculous fee. If I can get over the fear of injecting myself, your solution should make it very affordable. I’m still waiting for the syringes I ordered, but once I try it I’ll let you know how it works!
Hi Sara, do you live in the US? I am in Calif and am having difficulty getting the syringes without prescription. Also what type of sterile saline product did you find that is suitable for injection? How is your treatment going? Thank you and hope your health is improving.
Hi I was wondering how long your vial of 40,000 Methylcobalamin will last me if I have a shot of 2,000 a week . I am paying 20 a shot at a local clinic every two weeks. This is all they will allow. I felt better right away although I do not believe they are administering this brand of b12. more likely it is the cyanacobalamin. I am sure your product is more cost effective. I know I have intestinal inflammation and after finding this out the extreme fatigue and irritability etc. all makes sense. if you could respond I would appreciate it .
Thank you ,Cindy
Hello, what if I do not want to dissolve all of the powder at once? I have pernicious anemia, but would prefer the vial to last longer than 1 month (preferably 1 1/2 – 2 months) because I am currently unemployed and want the B12 to maintain it’s potency. I’m sure over time, the B12 mixed with the saline would slowly lose it’s strength. While I understand, I should intake more B12 than I am planning, I know that some is better than none. Looking forward to your reply.
Thank you for your help!
Amy
Try injecting every other day.
Thank you so much for this service.
I’ve received the order, I’m glad it got through customs, I was worried about that.
I’ve managed to find a sterile saline solution and started my b12 supplementation.
I’m so relieved and grateful your service exists!
I already feel a lot more like myself.
I’ve basically come alive again.
Thank you so much!
Hi Regev,
I’m 26 and don’t suffer from vitamin B12 deficiency, but it would still be alright for me to take a 0.3 shot of B12 weekly or do you find that unnecessary?
My parents are 60, so considered elderly. What is their recommended dosage and frequency based on their age? I’m in the USA and doctors here are reluctant to prescribe these shots unless there is a severe deficiency.
What preservative do you use in the B12? I can not tolerate benzyl alcohol.
Hello ? I’m from the UK and have been on intramuscular Hydroxocobalamin for 3 years. However our Health Service have reduced the injections. Is this B12 product as effective and can it be administered intramuscular?
Shalom Regev!
I can’t wait to receive your B12 in the mail! I am counting the days. You mentioned in your FAQ section that it takes about a week and half for delivery to the United States, correct?
Thanks in advance and congratulations and very grateful that you are providing us with the best form of B-12, methylcobalabim.
Best regards,
Raul
What type of B12 (cyano, methyl, etc) do you recommend?
We recommend methylcobalamin, especially to those with pernicious anemia. PA patients cannot metabolise B12 as normal people can, so absolutely need the only native forms of B12 there are, that is methylcobalamin or adenosylcobalamin. Patients with pernicious anemia commonly have other comorbidities like impairment of the methylation cycle which leaves them with extremely high and harmful levels of homocysteine. Methylcobalamin offers the methyl donor to eliminate the homocysteine thus addressing both diseases (pernicious anemia and hyperhomocysteinemia) with one treatment. Whatever you choose, avoid cyano B12. Since cleaving cyanocobalamin leaves a cyanide molecule for the body to eliminate, we cannot support any research that purports this cheapest and non-native form of B12 for any use whatsoever. Given a choice, who on earth would choose to put a non-natural cyanide compound in their body? It beggars belief!
I have been taking these shots weekly for the last couple of years. I give them to myself in the middle of my thigh muscle with a 25 gauge, 1 inch 3ml needle. I use .75ml B12 and .75ml B Complex. I never have sore injection sites because I warm the syringe under my arm for 5 or more minutes to bring it to body temperature and I take my time injecting slowly so that the muscle can gradually take it in. Most of the time I barely feel it. Doctor”s offices do not have the time to do this. That’s why they hurt.
These shots have been a God send for me. I do not absorb B vitamins orally and they upset my stomach. I do not take any other medication. I have lots more energy with the injections and they help with my immunity. There was a shortage last year and I got run down and sick without them. I am a pharmacy technician and I’m on my feet all day working with kids half my age and around sick people constantly. I need them! I get a real even energy from these injections, no shaking like with caffeine, and it lasts all week. I might also add that I was scared to death of needles before this, but syringes are so sharp and fine now that it’s hard to believe that you barely feel it, when it’s done right.
Hello Regev,
I am a Registered Nurse licensed in the state of Florida, USA. Recently, a friend & business associate stated that she had purchased B 12 injections through a special that a weight loss facility was promoting. She is not overweight, just “going to school & working, with 2 children”. She states that it helped her so much and inquired if I could administer those injections. I am presently an immunization nurse and have treated patients in their home under a doctor’s order. Those cases were diagnosed with pernicious anemia.
My question is, do you know if legally I would be able to administer the injections without being charged with something crazy, like “practicing medicine without a license”. When I attempt to look at the legislative codes in this state, it is totally overwhelming to try to find an answer to this question.
If you can possibly help answer this question, I would be very grateful. Thanks for all the wonderful educating that you are doing!
Respectfully,
Patty
The good news is that in the state of Florida a person can have anyone give them a shot without repercussion. For instance if a diabetic needed a shot they can have anyone they elect give it to them without needing a license. You cannot charge for the injections or do this in a clinical setting, but when not done in a business environment you are fine. Not all states are like this but in Florida it is fine. Hope this helps. We teach people to do the injections all the time. The other good news is we have not had any issues with people having adverse outcomes from poor injection technique.
I have been taking b12 shots for the past 6 weeks. I have a low thyroid hashimoto’s disease and also permanent muscle and nerve damage. I have noticed a big change in my energy but most helpful was that has happened with my muscles and nerves. I find this really helpful and will continue getting the shots.
Can pregnant or breastfeeding moms take B12-shots? Is the recommended dose same during pregnancy?
Hi Sarah!
It’s perfectly safe to get B12 shots during pregnancy and while you’re breastfeeding. If you’re deficient and don’t get the shots, you could have serious complications in your pregnancy or your baby could B12 deficient too, causing him/her numerous dangerous problems. The recommended dose is higher in both pregnancy and breastfeeding. In addition, you could need more than the general population if you suffer from a disease or condition that causes problems in the absorption of B12.
Hello Regev,
Thank you for your excellent site and product.
I have megaloblastic anemia, and have been trying different sublingual tablets in different doses. The methyl-B12 helps, the Adenosyl-B12 also helps, but I think I have been just holding still at best. I have been to 3 doctors, NDs all, who won’t give B12 shots. My opinion of doctors is very low right now, since I feel they have given me a long and drawn out death sentence.
And then I found your site.
On most lists of symptoms, which are fairly short, I have almost 100% of them. On your much more extensive list I only have maybe 33% which is encouraging for me. I just wanted you to know how helpful that symptoms list has been.
I just ordered again, 2 bottles this time, because I am playing with the dose. I started at .22ml because I have migraines which are sometimes caused by taking too much B12 at once. On the other hand, I very likely have them partly due to not enough B12 in general! Anyway, I am now up to .3ml and I will hold it here for a week and note how I feel. Then I may increase it by .02ml if I feel the need.
I have a question, and I understand that you don’t know my health history, but you now know I have megaloblastic anemia which I think is stage 4 of a 4-stage B12 deficiency. I also, unsurprisingly, have chronic fatigue and fibromyalgia and chronic migraines – all diagnosed by two different MDs. Can I take another shot in the early afternoon, right after lunch? My morning shot, between 9-10am, seems to wear off but I don’t know how a second one might affect sleep. I understand that only a certain amount is absorbed as a function of time, but might a second shot, spaced 4 hours later, be helpful?
I did read your entire site, but I will need to read it again in order to remember what I need to know.
If you have any experience with this, please advise.
Thank you very much,
Michele
I read that if I have 1000pg/ml, only about 5mcg floats in my blood stream, and that if i eat a steak my B12 for instance shoots to about 1500pg/ml for a short while, or an injection of 1,200mcg i’d get a recorded level of 250,000pg/ml for a few minutes! Is that true? If so, if I inject a couple times a day, will i have those levels in my blood around the clock? is that optimal for widrepsread healing? Same source wrote: “This is the magic range in which the MeCbl/AdeCbl can directly penetrate by diffusion into the CSF in sufficient quantity to stimulate neurological healing, remyelinating the nerves. People with low CSF levels of cobalamin need high serum levels to get that active B12 into the brain and spinal cord for some healing to occur.” Is that correct? Can neuroligical damage be repaired? Can the nerves be re-myelinated? I always thought damage is permanent, and injections can only make it stop deteriorating, not recover.
I’ve never heard of this. No one really knows where their problem in B12 metabolism lies. Is it in the storage of B12, or the bioavailability of B12?
There is no “magic range”. In medical research and literature there are no studies yet which elucidate what you are after. Instead of blanket google or ‘vitamin sites’ it is best to research what you’re looking for by reading published studies via https://www.ncbi.nlm.nih.gov/pubmed
Opinions do not matter. You need evidence. Right now researchers are still experimenting on rats so any evidence relating to human physiology will be a few years in the future unfortunately.
Methylcobalamin promotes the differentiation of Schwann cells and remyelination in lysophosphatidylcholine-induced demyelination of the rat sciatic nerve:
https://www.ncbi.nlm.nih.gov/pubmed/26300733
Human studies:
Vitamin B12-B6-folate treatment improves blood-brain barrier function in patients with hyperhomocysteinaemia and mild cognitive impairment:
https://www.ncbi.nlm.nih.gov/pubmed/12826740
Vitamin B12 in CSF: reduced CSF/serum B12 ratio in demented men:
https://www.ncbi.nlm.nih.gov/pubmed/1585799
For me, in addition to mega doses of methyl B12, I looked into Niagen, (NR – nicotinamide riboside), which converts into NMN, which converts into NAD which is needed in abundant levels to produce enough energy by the mitochondria for all cells to work properly, heal and repair. Energy issues have some degree of mitochondrial dysfunction due to not enough NAD. Nicotinamide is vit B3, but all forms, EXCEPT the Niagen (NR) and NMN pathway, are limited by the body in producing NAD. Only the NR-NMN pathway is unlimited in its ability to produce NAD.
I am heavily dependent in Methyl B12 AND Niagen both, and the Niagen was the next huge game changer for me.
Look up Dr Sinclair from Harvard and his research involving NMN with elderly 2 year old mice, and how, after a week of supplementation with MNM, these mice essentially had the cells of 6 month old mice and experienced dramatic reversals in aging, back in 2013. He actually has a pill now he plans to have on the shelf in 3 years, in clinical trials, to reverse aging. The FDA is closely watching, and has indicated to him they are considering labling aging a treatable disease as a result.
Niagen, the precursor of what he used, also dramatically increases NAD, and has been shown to do so in humans, as well as improve a host of conditions in recent research.
For me it has been absolutely invaluable in restoring to me my energy and life on top of my need for methyl b12.
Niagen is the patented form of NR, and only available from Chromadex under various independent labels. Any bottle should have both names on it somewhere, or I would consider it suspect (there are some out there). I have only been able to find it online. NMN is also available now, but is not controlled like Niagen is, so don’t know about quality control. I have found a sublingual form of NMN which works well, my only concern is it uses Xylitol.
I take methyl b12 until I can see it’s being excreted by my kidneys, urine turns yellow – usually 40 -80mg/day; and I take a baseline of 1000mg Niagen per day and up it from there as needed.
As I said before, Niagen has been a huge game changer for me. It’s absolutely given me my life back. Due to the way it has so dramatically helped me, it’s clear I have a severe mitochondrial dysfunction. If I stop taking it, my symptoms come back rapidly.
The only other thing that has significantly helped is going on a keto diet, as it’s easier for mitochondria to produce energy from ketones than it is from glucose (I also lost 40lbs in 5 months effortlessly).
I hope this info might help you as much as it has me.
Hi again
Just wanted to say that my wife is doing very well on the Methylcobalamin we bought from you. She’d been on hydroxocobalamin for some years now because of chronic fatigue but since the brand she was taking became unavailable and she had to switch to Neo B12 they were giving her migraines and somehow their effectiveness was also not as desired.
Thank you for providing this product. My wife has not had another migraine since she started on Methylcobalamin. We are re-ordering so that we’ll have spare which we’ll leave in powder form until we are ready to use it as you suggest.
Warm Regards,
Mark
Hi,
I recently purchased your b12 powder and tried to find saline solution that I could use, so I went to find some at Cvs etc. here in our place and I can’t actually find them, so my question is where do you usually get them, sorry this is my first time buying this b12 powder. Thanks in advance!
Could the B12 possibly help me if my blood levels seem normal?
B12 levels measure all forms of B12 in your system, not just the active forms, and there are something like 25-27 steps involved in converting the b12 you injest into the active forms, primarily methyl b12. That means your lab values are measuring all those analog (inactive) forms that are of no value in their inactive forms.
Additionally, the lab value range considered “normal” is way out of date and behind the times in the US. Where around 200 is accepted here as a low normal not needing intervention, other countries, like Japan and England, have updated their low normal values to be around 500-550, and consider anything less than this to be dangerous, even life threatening
The only way I know to easily assess one’s methyl b12 status is to measure one’s homocysteine levels, which, contrary again to US accepted normal high values, needs to be around 7 (rather than around 10-15). Methyl b12 is needed as a cofactor to change homocysteine back into methionine. If you have normal b12 values like I do, but high homocysteine like I do, this points to a deficiency or problem utilizing methyl b12. I need supplementation in large doses because of this.
Another way I discovered, but can’t find much supporting evidence for, is to pay attention to your body. Perpetual chapped lips are a sign of methyl b12 deficiency; missing moons on you fingernails, starting with your little finger first, moving to your thumb; verticle ridges on your fingernails starting with your thumbs moving to your little fingers. I was told these are signs of methyl b12 deficiency, which has born out to be true in my life.
When I take sufficient amounts of methyl b12, my chapped lips resolve, the moons come back, and after a long time, the ridges seem to lessen. If I consistently dont take enough, these all worsen. That’s in addition to all my other symptomolgy.
Can I still order B 12 (methylcobalamin) injections for B 12 deficiency from you directly?
I was helped immensely by them.
Two injections 10 days apart from a friend who was using it.
My doctor for some reason has a problem giving me an Rx. She says that the sublingual B 12 is shown to work just as well…..no so….not for me.
My blood serum levels show me to be on the low side of normal…..but in Japan they are treating people with much higher levels….with methylcobalamin…
I am 67 years old….MRIs, CT scans, and other blood work show everything to be normal…
Thanks you for your response
Sharon
Great article! Thankyou. I am experiencing neurological sx and can’t even get my doctor to consider a b12 deficiency. Just kept asking if I have a family history of autoimmune disease. I have two young children and since having the first have experienced numbness in my toes and fingers, as well as spasms in my hands, patchy red tongue, shortness of breath etc which is gradually getting worse and he completely disregards the possibility. I looked back at a blood test from 2014 and my blood serum level was 300, which I now know to be quite low, and may actually be even lower if tested properly. Extremely frustrating!
Shalom – I am grateful for finding your webpage it is a great resource of information and being able to buy the raw B12 here, is something I may well purchase, this month or next. After having issues with my menstrual cycle, with cycles every two weeks, I asked for hormone checks and full blood count, because in addition to that, I had memory loss, memory fog and short term, memory loss, which I thought might be oestrogen dominance, so I ordered some maca to help regulate. Also for months, I had pins and needles and terrible cramps in my calves, really severe, to cause limping the muscle was so sore, anyway I never put the two together until I got my results back from the doctor -to my surprise a number of issues were revealed, in my blood tests, which my g.p said I had nothing to worry about, revealed that I have macrocytosis. My most recent result was Mean Cell Haemoglobin (xe2pb) Above Range 32.2 pg [27.0-32.0] Above High Reference limited. My Doctor advised that was not the test they look, they look at the Mean Cell Volume (42A) 94.8 fL [ 76.0-98.0] which although high, was within range at 94.8 fL. So – I went away and looked up what the results all meant, then I looked up on the last bloods I had, and having being treated for autoimmune psoriasis this last year, I had a fare few to look back on, and even before commencing treatment for fumaric acid esters for psoriasis it clearly revealed MCV of 98 fL so I’ve had macrocytosis for sometime. So I will be taking up with the professionals, why they indicated that all my starting bloods were normal, before treating me for psoriasis which subsequently cause lymphopenia of 0.5.
So I’ve been anaemic for a long time, and apparently at least two years before symptoms, even show in bloods but the doctor just sent me away, even though, I printed out B12 deficiency, I thought he would, but never had not compared my other blood results at that appointment. Anyway all the advice online, indicated B12 deficiency or pernicious anemia due to the megablastic red blood cells, so informal advice said, if you have neurological symptoms take sublingual methylcobalin asap, and with the memory loss and the test result, I ordered some and this got rid of the memory loss, but I still get pins and needles, especially after dosing 5000iu am and 5000iu pm.
I also have really bad tinnitus, and wanted your advice on how to increase dosage upward to 60 mg effectively, as this was cited for treatment for tinnitus, although it may have been 60 mg ordinary B6 which would be no good if I have an un-diagnosed Intrinsic Factor antibodies, so I was really wondering having learned that sub-lingual tablets only allow absorption of 1-2 % how much absorption I would get from a 0.3 ml syringe per day of your supplied methycobalin? And do you have any information on this for the treatment of tinnitus?
If that wasn’t enough my blood also revealed that my TSH – Thyroid Stimulating Hormone was also high, with low hormonal output. Apparently people with megablastic anaemia often have hyperthyroid issues, my result was 4.01 mu/L [11.0 – 4.2] which was was point from being above range. Serum T4 was also tested as 16.8 [11.0 – 22.0]. So I set about to treat potential Pernicious anaemia with the B12 then I added methyl b6 and methyl folate and intend to tackle the other b vitamins along with zinc and natural kelp to try and get this system in order, which might well explain why my menstrual cycle is so messed up, no point in maca if the whole system is deficient.
So learning such a lot, in a short space of time and adding to this what I had already learned which followed the adverse treatment of my psoriasis is how autoimmune conditions need b vitamins and zinc for skin and muscles to function properly. I learned that high dose 0.3 grams of pure biotin is being used to treat m.s and has received good results for psoriasis treament, so I will be adding this to my b vitamin regime, once I get it all together.. not there yet. I have to treat the anaemia first, then I’ll extend to the b vitamins for thyroid, before undertaking high dose zinc treatment for psoriasis, because it is my thinking, that if I do have malabsorbtion issues of B12 then it is likely I may have malabsorbtion of zinc, which seems to operate with the same mechanism of parietal cells of the stomach, with the same rationale as sublingual, that if high doses, a percentage will get through. I wonder if injections would be better utilised? Will have to investigate?
I’m on a mission, and will sort my system, systemically and hopefully my psoriasis, far better than going on adulimab which could give my lymphocite cancer, and maybe relief from all my sorting out my body with simple vitamins and mineral and acknowledging I have an issue, and changing the way I look at me and my health. This really has been a wake up call for me and my personality as just like my body likes to attack me, I have some of those tendencies too, and I’m sick of it, I’ve had enough and their will be change… 🙂 There is probably loads of things, I have not factored in yet, such as adding pottasium or iron, but slowly slowly.. Niacin is another water soluble b vitamin, which like biotin, is supposed to beneficial at high doses, so will be including this too. I really just wanted to share this awakening with you and the many others that are finding this resource invaluable.
Toda
Chava
For more than 10 years (45ish-57yo F):
Consistent borderline low WBC & RBC, borderline high MCV & MCH.
To me (a layman), that indicated poor red blood cell production, and those that were produced were malformed and had short life spans.
Finally, a doctor tested for “Intrinsic Factor Anti-body”, which prevents B12 absorption. Result was positive. (Also, positive for MTHFR.) Diagnosis: Pernicious anemia/B12 deficiency.
Oral & even IM treatment with Cyano-B12 were ineffective, but IM treatment with your Methyl-B12 so far appears to be very effective. (Still some brain fogginess/memory issues.)
Please comment on blood factors, and IF anti-body (and MTHFR, if you would like). Also, need for methyl-folate over & above IM methyl-B12.
Thank you for all the information! I’m trying to save my life and my doctor knows less than I do now regarding B12 deficiency. I read: all your information and Comments, “Could It Be B12 . . .” book, and various published articles from Harvard, Mayo, and Cleveland clinics.
Female, 80, 234 lb (US), lung X-ray and standard bloodwork “normal.” Meds: inderal (arrhythmia), Valsartan & Amlodipine blood pressure pills, 4 potassium chloride football pills, Prilosec for hiatal hernia with reflux (many years), a statin, diuretic for swollen legs (wear stockings, losing weight helped).
SYMPTOMS: stiff knees hurt (only when bending); weak unless sitting; short of breath with slight nausea (walk or stand); oxygen 88 percent (finger tester) with any activity (95 percent sitting); poor balance of a 1-year-old (turned around quickly and fell); anxious for no reason (tap or swing foot-new symptom); numbness of toes (new symptom); low-grade temperature for six months (99-100.2 F–normal was 97.6 F). Need gluten-free (recent).
SOMETHING IS WRONG WITH ME!
I insisted on B12 test— result: 281, which doctor said was good (200-900 allegedly normal!); and he implied my complaints were all in my head from COVID and lockdown worries. His advice: Go outside, increase walking every day. I have no motivation to be ill; I am an independent investigator, with many kudos. I solve challenging cases for the fun and thrill of it (like a hobby, but I’m a pro). My mind is clear, but I temporarily forget names. I fear I will be destroyed soon—must act and care for almost-100 yr husband.
Doctor finally wrote me an Rx to self-inject 1 dose cyanocobalamin. I didn’t dare tell him the methyl type was better or that 281 was low, 500 is normal. He follows strict hospital and lab guidelines—no deviation allowed.
I have to save myself, so thankfully I read your information. ACTION—I :
* quit taking Prilosec and statin, cold turkey (thanks for info)
*sleep upright and eat 1/2 amount of meals to prevent any acid rising up
* failed to purchase the cyano B12 on purpose; I will order your meth B12
* take sublingual B12 1000 mcg in A.M., noon, and in P.M. (til injections)
* bought liverwurst to eat for breakfast and lunch (eat eggs, chicken often)
QUESTIONS:
(1) Should I request a follow-up B12 test three months after I begin?
(2) How can I test if I might be allergic to the methyl? Or, would a reaction be immediate after injection? (I can’t call Dr. because I’m not following his instructions and am probably on his “bad” list. I’m very nervous on my own.)
(3) What 0.3 ml injections Schedule would be appropriate? Duration, etc.
(4) Anything else I should do or know but don’t?
Thank you very much! You are much appreciated! It is frightening to act independently because my regular, board-certified doctor’s medical group is not up to date on B12 deficiency.
Thank you for the information. I was wondering if you believe saline to be the best thing to reconstitute the B 12 or if this other solution would be better?
Thank you for the information. I already self inject first cyano and now hydroxo for about five weeks. I hate it but I know how to do it. I have nerve damage due to long term undiagnosed pernicious anemia and am hoping methyl will repair some of it. Many thanks!
PS: my method is to use two needles. I draw the solution with a large needle, I buy them already attached to the syringe, then I let it sit covered for an hour to come to room temp. Just before injection I unscrew it and put a smaller gauge needle so the one I’m injecting with is pristine. That way I don’t have to worry if I ding it on the bottom of the vial.
Suggestion: add a few sentences about safe disposal of syringes. If you don’t have a sharps container any heavy duty plastic bottle with a screw top works well. Empty Laundry soap or juice bottles are good.
Can you please advise the size and gauge of needle? Just ordered your B12 😉
In Florida they have B12 stores where you can buy B12 in syringes. They’ve told me the needles are 28 gauge, 1/2 inch. I’d been injecting using them for about 2 months (until I found this place). Cannot feel them. And I hate needles!
Hi!
I was experiencing neuropathy in my hands and feet, having chronic fatigue and skin and hair issues. I was afraid it was diabetes but after tests my doctor informed me I had no detectable vitamin b12 in my system. He explained that often pernicious anemia is caused by an autoimmune reaction with the patient’s immune system killing off the intrinsic factor. After four weeks of once a week injections things started getting much better! Unfortunately I lost my insurance and without the regular injections am back to how I was previous to them. Now thanks to you I have the option to get some injectable b12 so hopefully I will feel well again soon. Thanks!!!
Morning
My daughter was bed bound with ME for 6 months 5 years ago and it was discovered she was deficient in B12. She has been injecting herself ever since. Initially a few times a week gradually decreasing – she now injects when she feels she needs to based on her symptoms. 2 weeks ago she was very unwell with severe abdominal cramps and told by her GP to go to A&E where she admitted to hospital but released 24 hours later with suspected UTI (despite 3 out of 4 urine tests not showing nitrites!). She was given a course of antibiotics. She has since been seen by a gynaecologist and given the all clear there but her blood tests (taken after she had finished the antibiotics) showed up c reactive protein as 24 and her B12 greater than 2000. She has now been referred to a gastroenterologist as pain is still present. She has not injected herself with B12 for over 3 months. Should the levels be that high? What else could it indicate? I am so pleased I have found your website as it will make purchasing future injections much easier.
I have been doing B12 injections for about a year due to inability to absorb properly. They have been a miracle worker. I take 1ML every 3 weeks. This has increased my energy level and stopped some of the problems I was having from it being so low.
Thank you so much for the very much needed education. I care for my grandmother and it just seems like she’s being tossed from one Dr to another with no answers. I feel more concern and more in control of her care now.
Just recently started hormone replacement. Was told needed b12 because red blood cell problem. Told should have b12 injections every 2weeks. Have received 2 injections thus far. Must say..instant feel better! Have been following your information. Thank You for much info! Seems with age we deplete so much!
ok here’s my symptoms: im always tired, I go up the stairs and I feel like im gonna die…and severly out of breath. Im constipated every other week. I sleep all day when im off work when I really should be doing things more productive, im mostly grouchy and always upset about something. My feet are swollen when I wake up and it makes it difficult for me to walk. These problems started almost 2 years ago after I had my last child. Am I the posterkid for someone who needs B12 injections? oh and btw im only 30 and im in law enforcement……its dangerous for me to feel like this. HELP
My daughter at age 3 developed diabetes,than slow grwoth and thyroid diease, than addisions, (adrenal faliure) than celiac diease, thatn she was in bed for years, doctors said ,mental and she was jsut tired of being sick, deal with it, I look up more diease that she could have(God forbid we need another one, Anemia!!! I was so angry. The doctor said no to B12, I got it anywasy. She went from sleep 24 7 and no enery, a stroke and no energy to up and moving, doing so much better. I am so angry!. She is a differnt perosn!. She has her life back. The docotrs still say it is not the B12, Really!!!!??? Nuts, she takes 1ml every 3 days and is bright an beautifu again. Look up Polyglandular Syndrome; lack of B12 is quite common. She is 37 now and we needs help. Had they not waited so long to do this she would be healthier. Her stroke and memories problems are because of B12 deficiencies. What a shame. But we got it now!
I’m 49 and stuck on disability due to 6 low back surgeries. Just found out I will probably have to have yet another surgery. I’m bi-polar, chronic severe insomnia and in 2012 was diagnosed diabetic within 3 months of diabetes the neuropathy in my feet became so severe I could barely walk. I have 2 spinal stimulators implanted for low back and feet. My toes are numb and feel like I’ve been walking barefoot in the snow for miles. I finally saw a medical doctor that is also certified homeopathic. He ran blood tests and I am deficient in zinc, D3, Tested positive for genetic defect MTHFR and prescribed 2ml a week B12 shots, multi-vitamin, B complex vitamins as well as Tryptophan. I fear a lot of damage is already happened but I pray since my B12 from you just arrived today it will hopefully minimize any further damage.
Apparently here in the USA the corrupt pharmaceutical industry has made the pure B12 illegal and the only thing they offer is the synthetic B12 that your body must work harder to convert. I just stumbled on this site and the wealth of information you offer is a blessing. Thank you with all my heart for the educational information and offering the good vitamin B12.
Kelly: there is a lot of corruption in Big Pharma. But Methyl cobalamin is NOT illegal in USA. You just have to get it compounds for you in a ‘wet compounding’ pharmacy. ( usually privately owned, not corporate). And you will need a prescription. So throw in the cost of a Doc visit.
There are several in my state alone (Colorado), but only on that is ‘wet’ for injectibles. AND—it is 5 doses for TWICE the price of the 33 doses available from good folks here at PerniciousAnemia.org. Order it from them here. Even with the (dirt cheap ) saline cost added and your needles, you are still way ahead.
Blessings on your healing way.
I read your book with much interest after trying B12 jabs and their amazing result at relieving symptoms. However, my B12 is not at a low level (it was around 850). I am the 2nd patient that my GP has in this situation and the other has found the same result with a number of her family members. I am now trying to understand why the B12 is getting to the blood (as my blood test reading says so) but not being used by the body without the strong dose from the B12 jab. Have you done any research in this area or know someone I might be able to speak to? Many thanks
I have bought the bottle using your link. However, I have not opened it yet as I have another bottle that is not yet empty. This new vial looks like it does not have a rubber top seal that a syringe would penetrate. I’m concerned about how sanitary the mixed solution might be if open to the air each time an amount is drawn. Does the new bottle have a rubber seal? I guess I could open it now but I’m not yet ready to mix and use the solution. Can you tell me how this is typically done? Or am I worrying about nothing?
BTW…I’ve been injecting Methylcobalamin now for about 5 weeks and have had a dramatic improvement in what I thought was chronic fatigue and memory/focus issues. I’ve enjoyed your site and am sharing it with anyone that will listen. Thanks.
Very happy to hear, George 🙂
All sorts of closures for the glass vials were considered for antimicrobial protection. Rubber closures actually allow ingress of contamination from the hole through which the needle passes, which is too large to keep out bacterial contamination. There are studies reporting that. Here’s one. Ensuring the vial remains tightly closed is best for maintaining the methylcobalamin’s integrity.
Also, rubber closures are prone to sample contamination by rubber additives. Here’s another abstract for your information. This is more well-known now and another reason to avoid that type of closure although there are still plenty around since they tend to be cheaper.
Anyway, always clean your skin (alcohol swabs are great) and wait for it to dry before administrating. It is the staph aureus on our skin that causes the most problems.
Hello
Thanks for this site! I have been diagnosed with vit-B12 deficiency and start injections next week. 3injections in week one and 3 injections in week 2 to get it into my system, then it’s every couple of months probably for the rest of my life thereafter. My deficiency comes from having a gastric bypass and unfortunately no amount of supplements have enabled me to absorb the right amounts.
I have lost 6 stone in 6 months since my operation, so I hope I don’t become emaciated looking.
Thank you again for shedding more light onto this.
Charlotte. :o)
Hello, Regev, I would like to ask you a question regarding B12, hopefully you are able to receive it. Several years ago while my wife and I were going through a regimen of tests to determine whether or not she had “memory loss’ and at what level. I suspected that she was experiencing some. The tests proved that my suscpicions were correct at that time she was diagnosed with “MCI” it has since been elevated to “mild to moderate dementia”.
Anyway in the process it was determined that my B12 levels were dangerously low. As a result I started receiving the monthly shot from the VA system until about a few months ago when they said they were no longer available and advised me to get a oral supplement from my local pharmacist. Which I did. Well I have learned thanks to your article and others that the shots I was getting may have been cyanide based. I will be checking with the VA next week. For certain the supplements which the pharmacist gave me definetly are (I stopped taking them immediately, and will go see the pharmacist today).
Here is the real issue at hand, I have been having numerous issues begining with “frozen shoulders” back on October. With cortisone shots and physical therapy I got through that and was given the OK to resume normal activity on December 15. After bowling two games on December 15th I bowled two practise games before going back to league bowling on December 16th. Well I made it to the 1st ball of the seventh frame with no issues, but when I threw that next ball I heard an audible “POP” and felt a great deal of pain. I managed to finish that game once again with a considerable amount of pain. I went to urgent care shortly thereafter and was diagnosed with a “traumatic rupture of beceps tendon – Primary”.
On December 18 I was seen by an orthapedic surgeon and an appointment was scheduled to repair it on January 7th. Everything was fine until December 19th when I was shoveling the snow from our deck and tore the bicep tendon in the left arm. So now I have two torn tendons and will undergo surgery to have both repaired on January 7th. Now the real question is it possible that the B12 injections with the cyanide base could have built up over time and be the reason for the weakening of the tendons and that it has also damaged other parts of my body (tendons) etc. and that I should be taking something else to reduce further risk besides a non-cyanide base Vitamin B-12. Hopefully you can provide me with some sort of resolutions.
Sincerely,
Jerry
Hi Jerry, it’s unlikely for cyanide to cause your tendon issues. Without liver/kidney damage and with enough methyl groups, cyanide will not build up in your body. However, your B12 deficiency itself could be the cause for your frozen shoulder and muscular weakness, and combined with sudden physical activity could be the catalyst for a sudden traumatic tendon rupture.
This is a long post, but I hope it contains some useful information for others.
Something that is missing from the site as a cause of deficiency of methyl B12 are mutations in the MTR and MTRR genes. These are some of the methylating genes of the body and very important in methyl B12 production and utilization. Mutations in these genes can cause a deficiency of methyl B12 through two avenues – one impacts the availability of methyl groups to form methyl B12 and the other cause the body to use up methyl b12 too fast, so that the body is in a state of deficiency (even if blood serum levels of B12, includes inactive forms, are normal).
The simplest way to test for this genetic cause is to test one’s Homocysteine level. Homocysteine should be around 6.5-7.5 though often lab values for high normal will be around 10 or 11 or higher. Homocysteine is an amino acid your body makes from Methione (which has to be ingested being one of the essential amino acids our bodies need to get from our diet). The body converts Methionine into Homocysteine then back into Methionine and this continues in a circle. (This is an overly simplistic explanation but essentially correct). This is the heart of the methylating cycle of the body which is essential in a myriad of ways.
If the body cannot convert Homocysteine back into Methionine, or be broken down and excreted, then Homocysteine rises and causes all sorts of problems as it is highly inflammatory. This is one of the causes of cardiovascular disease for example through inflammation of the inner lining of the arteries leading to artherosclerosis. Elevated homocysteine also causes thickening of the blood and can help lead to blood clots.
The reason Homocysteine is a simple test is because methyl B12 and methyl folate are used together as “co-factors” to change homocysteine back into methione. If there is not enough methyl B12, then this conversion cannot take place effectively, and so homocysteine rises. To know whether or not methyl B12 is indeed the culprit vs methyl folate, one can simply start taking very large doses of methyl B12 and see if their homocysteine responds. But if one really wants to know, one needs to know their genetic mutations in the methylating cycle – MTHFR, MTR, MTRR genes for example. An easy way to do this is to use ’23 & Me’ which will provide one’s raw data, then put that data through a service such as Genetic Genie (which is free service created primarily to help with autistic children, though anyone can use it). Genetic Genie will generate a report showing you your mutations with explanations as to what each one means. MTHFR mutations will affect methyl folate, and a combination of MTR and MTRR mutations will deplete methyl B12.
When looking at genetic tests, this is important to keep in mind: just because you may have genetic mutations in this area, does not mean they are “expressing” – ie causing problems. But they could be; or if not now, could at a later time. This is why it is important to know one’s homocysteine level as it will be an indicator as to whether or not they are causing a problem.
I would recommend checking for methylating defects for anyone suspecting a problem with methyl B12, and especially if their homocysteine is elevated. Elevated homocysteine is a red flag.
I was excited to read about how easy it can be to get methyl B12 in a pre-injectable form that you can mix yourself. However, for me, the the solution offered here is way too cost prohibitive. This is because, due to such mutations in MTR and MTRR mutations, I have found I need 20,000 to 30,000 mcg of methyl B12 A DAY before it starts spilling over into my urine (at which point I am sure I have enough for a bit as now my body is excreting it), and to lower my homocysteine and keep it lowered.
I track this in 3 ways.
The first is through my homocysteine levels, but this can be done only as frequently as my doctor is willing to order the test.
The second way is by using the color of my urine on a daily basis as an indicator as to whether I have enough in my system. B vitamins turn our urine yellow. If it is clear, then there is room for more methyl B12. This means I can’t take any other B vitamins as then I won’t know which is turning my urine yellow, and other B vitamins are necessary too.
The third is my symptoms. What it takes to lower my homocysteine is not enough to manage my symptoms.
Injectable forms of methyl B12 have turned my urine red in the past, so I was excited to find an easy way to obtain this form. This would allow me to separate the methyl B12 from the rest of the B Vitamins when using color of urine. But, at nearly $100/40,000mcg, that would amount to close to $3,000/mth given the doses I have found I need to help reverse my symptoms (which were severe). 🙁
Another method of delivery not mentioned in this site is sublingual doses. These vary from liquid you hold in your mouth, to dissolvable tablets to “dots” you hold under your tongue. Sublingual delivery can rival injection as it bypasses your digestive system and enters your blood stream through the buccal mucosa.
I guess I will still need to still rely on the dots for now.
In regards to comments about CFS (Chronic Fatigue Syndrome) and how to deal with it. I am speaking from personal experience: This is VERY IMPORTANT.
First the PACE Study, which many doctors rely on, is very flawed and no one should be, in my opinion, allowing their doctors to recommend graded physical exercise because they ‘need to get over their fear of activity.’ Please read up on the recent court case forcing the PACE researchers to release data they had refused to release and how they changed the criteria mid trial for recovery to make it easier to qualify people as “recovered.” When their hidden data was applied to the original criteria, there was no objective evidence for recovery in any of the subjects using the two pronged approach of psychological intervention and graded exercise.
But more importantly, read up on the research being done by Dr Sinclair at Harvard University. He was named one of Times Top 100 People of the Year in 2014 for THIS discovery: The basis of disease and aging is something called Mitochondrial Dysfunction. His discovery demonstrated that by increasing something called NAD+, he could reverse the cellular age of mice.
He found he could do this by using a special form of Vit B3. He took 2 year old mice, gave them this special form of B3 in their water, and a WEEK later checked their cellular age markers: They now had the cellular age markers of 6 month old mice. He has said their cells were indistinguishable from the younger mice. This is like an 80 year old having the cells of a 30 year old.
The form he used is very, very expensive, but the form immediately before it isn’t, and has been made available as a supplement – nicotinamide riboside, which can only be purchased as a supplement under the name of Niagen.
Now it was just in the news last month that Dr Sinclair is about to start clinical trials with a drug that has been formulated from the form he used: nicotinamide mononucleotide. This drug is expected to be available in 3 years to REVERSE AGING. It does so by raising levels of NAD+ so that the mitochondria can produce abundant levels of ATP – the energy our body relies on to work correctly. This abundance of ATP allows the Nucleus of the cells to REPAIR DNA DAMAGE. If you research this, you will find NASA wants this so that the DNA damage caused by cosmic radiation can be repaired in astronauts in space. This is real. It is really happening.
Even though it will be a few years yet before this drug is available, Niagen is available now. Niagen raises NAD+ as nictinamide riboside becomes nitotinamide mononucleotide which becomes NAD+ which then allows the mitochondria to produce abundant levels of ATP energy. I can personally attest to how quickly Niagen, nicatinomide riboside, increases cellular energy and can make a dramatic difference in someone suffering severe symptoms of CFS. I am not associated in any way with the pharmaceutical company that makes Niagen or any company that distributes it. I’m sharing this because, as someone who suffered the serious effects of CFS for 10 years, this has been a profound life-changing intervention for me, and has been hugely instrumental in giving me my life back. For me, taking Niagen for the first time was like being plugged into a nuclear power plant.
I take a variety of supplements, each for a particular reason and only after having researched them. The main supplements I take are methyl B12; Niagen; D3 with K2; and new supplement from Live Cell Research called CL-5 (which is geared to reducing cortisol, and immediately increased stamina, strength, and endurance, curbed all my food cravings and overeating, and allowed me to start losing weight); and a nitric oxide (NO) supplement – a special note on this last one: even though I had started losing weight with CL-5, as soon as I introduced the NO supplement, my weight started literally melting off.
Regarding Nitric Oxide – I would like to recommend a book: “The Nitric Oxide (NO) solution”. We need an abundance of NO and we get that through diet and exercise. It needs to be constantly replenished to prevent and reverse chronic disease. I know as soon as I started adding a NO supplement, weight began to just fall off. I can’t really comment on what was shared by another poster as to higher levels worsening symptoms in CFS patients, but I can share the NO supplement is what I added last, after addressing my CFS symptoms primarily through methyl B12 and Niagen and then CL-5. so the reason I may have benefited so much from the NO supplement is I was already on the road to recovery.
For people who really want to understand what B12 deficiencies can do, I recommend the book “Could it be B12? An Epidemic in Misdiagnoses”.
I hope that this information might help someone else.
My B12 level tested at 38!! I’m on once-a-month injections, but it’s still very low. I’m scared. Please help me. Doctor said he didn’t know how I was alive.
Why is your doctor only giving you injections once a month? Please read the book “Could it Be B12? An Epidemic in Misdiagnoses” – perhaps have your doctor read it too. I would think you need daily large doses of B12 to get your B12 up quickly. Sublingual dots are not affected by absorption problems in the intestines, as they are absorbed in the mouth, and will help supplement what the doctor is giving you; but monthly injections are too far apart imho. You can bring your B12 up quickly and ensure you have the active form – methyl cobalamin by taking sublingual (under the tongue) dots in that form (methyl B12). B12 is water soluble so it isn’t toxic, especially when taken in the methyl form – anything you don’t need will be eliminated in your urine.
If you’re still alive SUE YOUR DOCTOR! You can buy injectable B12 and do it yourself, or find a nurse friend or similar to inject you daily. DOCTORS ARE KILLING PEOPLE WITH THEIR IGNORANCE ABOUT B12 DEFICIENCY.
At a certain point, I believe we have to decide about whether or not to take charge of our own health. I know many people who go to their doctor and ask about B12 only to be shunned or at best given a once every 2-week shot of Cyanocobalamin. If you ask about Methylcobalamin it is likely your doc will not recommend it because it is not the treatment protocol he was taught or it is not a treatment specified by his or her local health authority. The articles on B12 by Regev Elya are excellent. Don’t assume that what your doctor says as 100% truth. You are not being lied to, it’s just that they may not be aware of all the facts. If you think you may be B12 deficient it is my personal opinion that you have nothing to lose by trying it. The website has links to where you can buy it. You may be doing yourself a huge favor by trying it. I did and it changed my life.
Four months ago, I was diagnosed with b12 deficiency and my iron was fine. Now my b12 is 579 and my iron is very low. I’m confused because I still have joint and muscle pains. Could this be because my iron is low or I’m suffering from something else? Depressed
579 is really low. In Japan you would be on daily injections. Among the many problems we’re fighting is that US levels are LOW and UK levels are only slightly higher – what are deemed to be be acceptable/normal health levels, I mean…
I have hypermobility syndrome (hypermobile Elhers-Danlos syndrome -hEDS), and hypthyroidism. the second of which is often implicated in B12 malabsorption and the first of which is often associated with digestive system problems, malabsorption of B12 being one – though not all that common. What hEDS IS know for, though, is chronic acute pain, but it was only a few years after diganosis with hEDS that I learnt that B12 deficiency can also cause severe muscle pain. I know very little about iron deficiency, so will not comment.
Hi! I’ve been getting B-12 injections for right at a year now from my doctor once a month, When I first started getting the shots I felt the extra boost of energy. But after a few months it slowly decreased. For 2 months now I have been taking B-12 1000mg oral pills with my monthly shots and I have no energy at all! I can barely get out the bed at times. I don’t understand what is going on. Any suggestions?
It’s likely that B12 is just one of many factors in your fatigue. Injections make a massive difference for me but I also suffered chronic acute tiredness and hypersomnelence for years until I was finally diagnosed with hypothyroidism earlier this year. I still get fatigue – and depression, anxiety and a few other issues without B12 shots, but the l-thyroxine (aritficial thyroid hormone) has revolutised my life. Now all I have to cope with is chronic acute pain, but that’s a different story, and at least now I have the energy to perform my specialist physio etc. But numerous dietary deficiency as well as wacko sounding stuff like over-exposure to strong electro magnatism can cause or contribute to fatigue, as well as countless illness and infections. Not wishing to scare you, but everything from lymes disease to MS should be considered. It’s scary, but this is reality not a comic book. I’ve had three careers and the chance of a family stolen by illness, so I’m not wanting to be a harbinging of doom, just practical realist. Hope it’s just something simple and easy to resolve though.
Hi
I have B12d due to PA. my query is really a general one, actually several.
1. When B12 is injected and goes into the blood stream, does it then go through the hepatic system and gets stored in the liver, whilst some stays in the blood for distribution to the cells? or does it all go to the liver and is then distributed from the liver?
2. subcut v IM. Whilst adipose tissue slows down the absorption of anything injected, can adipose tissue block absorption of B12, epecially where a person is clinically/morbidly obese?. I understand that it is thought by some people that it is better to inject subcut as it is then released slower and less B12 is wasted. However, having trained in midwifery, it is my thought that injecting IM is quicker and more effective and you require a smaller dose?
Regards
Ellen
B12 deficiency is not something to be taken lightly and having injections for the sake of it just in case is foolhardy because ignorance amongst physicians is dramatic and if you do have a serious deficiency, ignorance amongst clinicians can greatly decrease your quality of life and even lead to death if not correctly diagnosed and treated.
To be clear, I am NOT a medical doctor but I do have hypermobile Elhers-Danlos Syndrome (hEDS) and through developing chronic fatigue whilst taking a psychologt degree five years ago I decided to write my thesis on living with unseen chronic conditions, which led to interviewing someone with the same condition who had previous suffered three years of chronic fatigue which is now managed – not cured – by regular B12 shots. One thing to make clear hear is that I’m talking about fatigue which is clincially chronic (lasting, or likely to last, six months of more) NOT chronic fatigue syndrome.
Through a further few years of serious research – and I mean clinical studies and serious academic work; not some blogger’s opinion or “Dr. Google” – I ascertained that around 75% of people with eHEDS suffer autonomic nervous system problems, one of which is malabsorption of a variety of nutrients, and in some of us this includes B12.
I also discovered that what are deemed normal B12 levels here in the UK are would be deemed borderline deficient in Japan – which led the world in research as of 2012-14 – and UK levels are higher than those deemed “normal” in the USA.
Most alarming is that the most common test for B12 – the first-line assay (blood tests) can return a false-positive as much as 35% of the time; this is not merely because the test is essentially useless but because many factors – some of which are mentioned above; such as folic acid levels – can interfere with test results. This means more involved tests are required to be certain – but here’s the real pig: most doctors will not consider more thorough (i.e. reliable tests) unless the first line tests indicate deficiency – even though those tests are essentially useless in most cases.
Fortunately, through the tireless efforts of orgnanisations such as the pernicious anaemia society the word about B12 is very slowly filtering through to physicians but not so happily, it’s likely to be another generation of two before things really change.
In terms of actual usage, when I first started receiving injections, when it kicked in after about four or five days, I went from feeling like I was made of lead to feeling like I was flying; I had not had so much energy in years. It took two more years of hard fighting to get regular monthly injections – because in the UK the few lucky enough to get them usually only get one a quarter – even though the latest research strongly indicates that people who are deficient should have injections every few days to begin with, and these should then be spaced incrementally until the person’s natural level of need is determined – for some this will be every few weeks whereas for others every three months actually is fine. For me it’s every five to six weeks; if I do not get injections this often I begin to flag to the point where, after about ten weeks I can hardly move – on top of which acute anxiety and depression also begin to return. I Know this because my GP wanted me to stop after eight months just to be sure, and I have had a repeat of this recently when I was in hospital for ten weeks following an accident and it took two weeks after discharge to get an injection; results: about 14 weeks without an injection put me back in hell and I have just had to order more injections online because my doctor will not give me one every few days so I can catch up again but now that I’m getting back to normal levels my energy is rocketing again and my anxiety and depression are rapidly fading.
Ultimately, as discussed above, B12 is vital for life but ignorance amongst doctors can cause fatalities – just look on youtube for treating B12 deficiency and watch the documentaries with real medical doctors (be very wary of nurititionists as anyone can call themselves such whereas dietician is a protected medical title – here in the UK at least).
I could go on for weeks because I’ve become something of an expert in this area of pure necessity because I was literally suicidal because of my fatigue and had my dissertation research not led me down the path it did I might still be in hell of actually dead – either at my own hand, because chronic fatigue is a living hell, of through irreversible neurological damage.
So I will say just three more things, two of which are touched on above: B12 is stored in the liver for when we need it and normal dietary intake does not need to be high, but if you can’t absorb it you do need injections; global rates of deficiency are rising because B12 is not actually produced by animals unless they are picking up mirconurtrients – such as cobalt- and microrganisms that a natural diet gives (i.e. cows should grace in fields not be fed pellets in a shed, etc etc); and thirdly, the type of B12 injections do matter, with cyanocobalamin being the worst of the lot – though better than nothing if it’s all you can get. For the record, there are very very few non-animal sources of natural dietary B12 (i..e not fortified cereals, breads etc) which include only a few types of fungi and some seaweeds, to the best of my knowledge. Which is why vegans and strict veggies need to be really smart about their diets.
Oh yeah, in addition to hEDS, I have also recently been diagnosed with hypothyoroidism, which causes chronic acute tiredness and hypsersomnelence (sleeping absurd amounts – up to 100 hours a week), but can also be a cause of B12 malabsorption, and I had this WITH chronic fatigue, so now I’m getting both thyroid meds and B12 shots I feel 30 again – I’m almost fifty, for the record.
Perhaps one more thing: read the guidelines from the British society for haemotology. And don’t go getting injections you don’t need, that’s just plain stupid.
http://onlinelibrary.wiley.com/doi/10.1111/bjh.12959/full
Hello Regev. I recently bought the methylcobalamin vial and was wondering if the vial is reusable. Is it safe to refill the vial with 40mg of pure methylcobalamin powder, then dissolve it the same way as the first time?
I would never re-use a vial as there are no guarantees it would remain sterile.
Hi, I just read your book which is very interesting- thank you. I have recently been diagnosed with b12 deficiency (level 95) but on the NHS they will only give me one injection every 3 months. As I have neurological symptoms, I want to self-inject to help myself! Before I saw your solution to buying b12, I ordered ampules from a German pharmacy online- of hydroxocoabalmin. In your opinion will they be ok for me to use and self-inject with? After I run out of them I may order from you instead! Thank you.
For most people methylcobalamin is preferable to hydroxycobalamin – it reduces high homocysteine levels, supplies you with a methyl donor, and doesn’t suppress nitric oxide. Still, hydroxycobalamin is much better than cyanocobalamin.
Thank you for your quick reply. I’m quite scared because my gp surgery seems to completely disregard the NICE guidelines. My gp said he did not consider 95 to be that low and he wasn’t convinced my memory loss and numbness was even related to b12.
Do you know of any b12 specialist doctors in the UK I could see privately? I’ve searched but can’t seem to find any. I’m based in Cardiff.
Your book has been a great help, it feels as though most doctors in the UK don’t know or care about b12, so it’s good to see that somebody does!
Penny, if you have neurological problems, you need 3-5 MG per injection, not MCG. I cured an eye problem using Methylcobalamin B12, which i had for 4-5 years. I injected 2 times per week.
I also ordered Hydroxocobolamin from Germany but haven’t received it yet. How did you do with it? I’m wondering if I’ll try that first and if I don’t like it then try this kind of Methylcobolamin. I was always told there wasn’t scientific research on the Methyl as there has been for Cyano and Hydroxo and there’s no written protocol on how to take it for B12 absorption issues. Maybe now there is more evidence. Either way I’m curious how you did with the Hydroxocobolamin from Germany.
Hello, Regev.
I just received my first order of methylcobalamin. However, there is a problem. The sealed vial is empty! Please see attached pictures.
Please Express deliver a replacement!
Thank you.
Look inside, there’s a tiny bit of red powder (that’s the methylcobalamin B12). The vial will become full once saline is added.
We looked again. Actually, upon looking very closely, there is something in it, but it is hard to see because there is so little of it. There is not even enough to cover the bottom of the vial. We were comparing it to the same-size vial we got from TeleWellnessMD. 50mg of powder fills half of the vial!? Why such a difference? Thanks.
Attached is a picture showing how little powder is in the 40 mg vial of B12 next to the 50 mg vial we received from EmpowerRx (TeleWellnessMD). Regev, please explain why the amounts seem so disparate. It is difficult to accept that the 40 mg vial from you is not a production error. Thank you.
This is not a production error. When you mix the 40mcg powder with 10ml saline, the entire vial will fill up. I’m guessing the vial from EmpowerEx is already in liquid form?
No, what I got from EmpowerRx also is powder, too. It requires 5 ml of bacteriostatic water to provide 50,000 mcg / 50mg. That gives her 2,500 mcg per 0.25 ml. Your vial says it contains 40 mg of powder. It requires 10 ml of saline, which the instructions say will provide 2 mg (2,000 mcg) per 0.25 ml. Regev, I have a degree in chemical engineering. Trust me and the pictures I provided. There is just a trace – not much more than residue – of powder in the vial I received from you.
Please see the attached photo to help you visualize what 40mg looks like compared to something you are familiar with. All vials are checked before they are sent, and no vial leaves the laboratory empty. I am sure you’re familiar with the size of Tylenol (compressed tablets) and other common medications. 40mg does not take up much space at all.
I admit you provide an interesting picture demonstrating different sizes, but “mg” / “mcg” are measures of weight, not volume. The most direct comparison I have is the picture of the 40mg of M-B12 from you, and 50mg of M-B12 I received from EmpowerRx.
It’s not even close! The M-B12 in your vial does not even cover the bottom of it. (In fact, the amount in your vial does not even look like as much as seen in your picture.) The M-B12 vial from EmpowerRx is half-full.
As a chemical engineer, I cannot conceive how this much of a difference is possible. Can you provide me a back-lighted picture of another of your vials containing 40mg of M-B12 for confirmation?
Mike, obviously ALL of these are weighed! Who on earth is talking about volume – but you in fact noted that the volume in the vial didn’t look like it was 40mg.
You are creating a storm in a teacup. I have been providing pharmaceutical grade Methylcobalamin for years. GMP accurately weighed on laboratory balances.
I have absolutely no idea why someone who calls themselves a chemical engineer cannot conceive of how small an amount 40mg is. Yes that’s 40000mcg.
If you’re not happy send the vial back for a refund.
Mike, after only 10 seconds reading the internet website for EmpoweRx’s methylcobalamin it is clear that you are comparing apples and oranges!
I assumed that a chemical engineer would know the difference between LYOPHILIZED methylcobalamin and 100% pure pharmaceutical grade methylcobalamin.
Since lyophilization is accomplished by dissolving the substance in a solute to begin with, and Empowerx do not tell what solute they use, (hopefully not benzene) then this obviously accounts for the difference in volume which you have so clearly noted.
I have included a screenshot to save you the hassle of having to click to go to Empowerx’ site:
Well, you got me. I was not familiar with lyophilization. I never came across it in a refinery environment, or plastics manufacturing. So, mea culpa, mea culpa, mea maxima culpa!
Hi there,
Thank you for this article it’s very informative.
I have been very poorly since having spinal surgeries 12 years ago and have suffered intense pain all over my body,nerve pain, chronic fatigue, burning all over my body,(my feet feel as if they are being crushed) chest pain, heartburn, headaches, forgetfulness, depression, loss of smell and taste, I have been under the care of my GP, neurosurgeon and pain doctor for 15 years and have had all kind of tests done but they have all came back with nothing to explain my pain, two weeks ago I saw a different doctor who ordered different blood tests and it came back that my B12 was dangerously low (48) and my vitamin D is also very low, my doctor has ordered B12 injections (6 shots every other day) and then 3 monthly shots and also vitamin D supplements. I have already had 4 shots and have noticed a fast difference in my chronic fatigue and my foot pain, I have been referred to a cardiologist to check my heart. My question to you is how long could I have been deficient with all of the symptoms I have, do you think they are reversible and what permanent damage could it have caused me ? I have practically been house/bed bound for 12 years and made to feel like it was all in my head, even referred to a psychiatrist!! I would be forever grateful for any reply from you,
Kind Regards
Jules
Hello, currently I am undergoing treatment for b12 deficiency. I initially had anxiety attack, breathlessness and tingling, I went to my family dr and told him these symptoms: extreme fatigue, headache, insomnia, tingling and numbness in arm and feet, body pain specially arms and shoulders, dr said might be b12 is low, he gave 1 methylocobalamin injection 1000mcg. After few minutes my anxiety and breathlessness was gone, he gave 5 more injections 1000mcg alternate days. Today after taking all, I went to dr and asked for more injections, since I was not feeling much better, just anxiety and breathing problems were gone, then he said I don’t have b12 deficiency now, I might be having these due to low bp. My dr didn’t even recommended b12 test before injections, so I don’t even know what my level was before, do you think I should continue injections or it could be something else??? My hb is 12.4 , liver tests and tsh is fine, sugar is fine. He says b12 can’t be low bcoz otherwise your hb would also have been low
While receiving B12 shots I felt like my skin, hair, and body overall looked and felt healthier versus before B12 use. Shots temporarily cured my still unknown, less frequent, symptoms of dizziness/light headedness.
Hi Regev,
I bought your B12 but need the saline. Could you tell me where i can get it. I went to drug store and saw all kinds of solution for eyes. Is this what I need? Could u tell me a brand name to get. I do not see why it would be that different but just in case i thought i would check. Drug store pharmacist not helpful lol!
Thanks
I bought both syringes and saline off Amazon in the US, if that helps. Best wishes!
I’ve developed severe neurological symptoms just before my period and at the onset I developed a migraine much worse than when I was on Hydroxo. Did some research. Some are saying it could be the methylcoblamin cause of methylation. They suggested methylfolate supplements. What do you think? Can you help in any way? I’m in agony. Been like this for 2 days. Because of my ME I am very sensitive and a lot of meds and supplements don’t agree with me. To think that I was doing so well!
Methylation does not cause headaches.
Most folks with B12 deficiency issues have other medical issues as well. A common comorbidity is histamine intolerance. Histamine intolerance causes horrendous headaches/migraines.
Check out this book to better explain it:
What HIT me? Living with Histamine Intolerance: A guide to diagnosis and management of HIT
Most people suffering these types of headaches are helped greatly by this antihistamine which seems to work best in relation to histamine-induced headaches. It is available over the counter and it’s common to take in the evening.
https://en.wikipedia.org/wiki/Diphenhydramine
Kind regards
Hi Regev,
I love your site. I’m a 45 year old male and I’m suffering from serious neuropathy from diving due to I was exposed to oil fumes from a job I was on in 2009. During the dive I didn’t felt anything even though I could smell the fumes from the oil but during my deco stop both my arms and hands lost total feeling and my torso started to go tight. After flushing my helmet with fresh air, I started regaining my sense of feeling on both arms, hands and my torso opened up. After that episode I never felt it again. I was a heavy drinker and smoker that time and after a year or so I started having episodes of neuropathy (numbness rather than pins and needles and sometimes all together) on parts of my face, sometimes my tongue and upper lip, one side of my head and ear. And sometimes numbness with some sort of pins and needles on my left neck, trapezius, shoulder and chest at the same time. This neuropathy feeling usually happens the day after drinking and worst when hung over. I stopped all vices for over five years and I was taking methylcobalamin tabs 500 mcg twice daily and the symptoms stopped after a year or so but with occasional symptoms for a couple of years after that. I started drinking and smoking again about 3 years ago but no symptoms. Last June I was on a diving job and after about 2 months diving with no symptoms we started a heavy job diving back to back non stop for 12 hours each shift (just for your info, one diver one dive only each day)I started feeling the numbness on parts of my face, one side of my head and ear (right side) including the numbness with pins and needles on my left neck, trapezius, shoulder and chest again but now with extreme itchiness on my whole chest, torso and love handles. This happens usually about 30 to 45 mins after I dive and it last for a few hours. At first I thought it was decompression sickness but it was not because the symptoms go away after a few hours and it only happens every time after I dive and not breathe pure oxygen for decompression. The only thing I can think of is that I was breathing fumed contaminated air that came from the main exhaust of the vessel. this happens when we charge our air cylinders and the intake of the air compressor is taking in contaminated fumes from the exhaust. I don’t drink much any more but if I do, I kinda drink a lot. I’m feeling the neuropathy again the day after drinking heavy and sometimes after I smoke a cigarette. Do you think your product can help me with my neuropathy? Besides quitting smoking and drinking less or completely stop drinking? If it can, what would be my daily dose and for how long? Hope to hear from you soon.
Thanks and best regards,
Anthony
I am a student Midwife and am researching Pernicious Anemia for a client. Her overall Hgb is 7.4 which will remove her option of a home birth with us so I was tasked with doing some. digging. She states the PA is a trait in her family and they take an OTC B complex supplement bit have never done anything else. She is currently 34 weeks gestation, would starting injections of B12 be helpful for her home birth status at this time or do they have a longer time frame for showing improvement?
Hello,
I just purchased two vials as I have MTHFR and I’m tired of having my doctor give me the shots and I need them daily which they don’t understand. I have significant brain fog so I just need assistance in buying the saline. This is something I can get from a US pharmacy without a litany of questions as to why I want it? If not, can I simply use bacteriostatic water? Also, I want to confirm that for each vial I bought I want 10 of saline per bottle to mix and this will give me how many injections? Can I profile the syringes and store in fridge in dark container? Thank you for your help. ~~Carolyn
Hi Regev – I’m excited to get this order. I have pernicious anemia and I’m suffering from a lot of ‘brain fog’ that’s really impacting my job. I only found out that I have pernicious anemia one year ago at the age of 41. I spoke with Becky Stella about her experience after reading her testimonial on your site. She was so helpful and gave me the confidence to place an order for an overseas, over-the-counter product. I am hopeful it will help me as much as it does her…. the B12 shots I get from my doctor just aren’t doing it and I know there must be a better solution. Thank you for making this available!
Best,
Amanda
I was recently tested and my ferritin serum level is at a 3. My hemoglobin is an 8.8 and B12 is at a 288pg/ml my Dr. Said there were “no significant abnormalities” but I feel SO TIRED all the time, chest pains occasionally, headaches everyday and numbness and tingling in my hands and legs/feet. Should I be concerned!? Should I change doctors?
Hi there! I have had a multitude of symptoms for years and just last year was diagnosed with Pernicious Anemia. According to the neurologist I was sent to for my migraines, my level was at 30. I was then referred to a hematologist whom had me on one injection per day for 7 days, then once every two weeks for six months. After six months my numbers were around 942 and he now has me on one injections per month. I am supposed to have a recheck next month. To this day I still have trouble speaking correctly about 40% or more of the time (including pronouncing things weirdly or with an unknown accent), still forgetting what things are called, exhausted all the time, urinary incontinence, and many other symptoms. Even my hair (I’m 35) is still turning grey enough to a point of turning white. Once it turns solid white, it falls out. My question is this: how bad is it when the level is as low as 30 and why would I still be having these issues if my levels have drastically improved? Thank you in advance!
Thank you so much for this information. When you say start treatment right away do you think 1000 mg injection once a week is enough if your levels are as low as 180? Also wondering if I’ve had two months of shakes, tremors, vision issues, tingling and numbness, is it likely that it will be reversible and go back to normal since it’s only been a few months or is there still a chance it’s permanently damaged the nerves? Thank you so so much for this site, it is very helpful in a frustrating situation. I went to eight different specialists until myself doing further reading on B12 and requested a test, Is it normal for Western medicine doctors to not look into vitamin deficiencies?
My 44 yr old daughter has had symptoms of fatigue, pain in legs, numbness in arms, memory issues and a weight gain of almost 60 lbs over the past year and a half. She finally found out on Dec 27 2016 it was her B-12 level (258) injections were started with 2 months of weekly and then 1 monthly. Her level had hardly increased so did 2 more months of weekly. She also wakes up occasionally vomiting. Her current level is 288. Am very worried she has pernicious anemia. Diagnosed in a couple generations of family. She was sent to a Neurologist because they thought she might have MS but that was negative. Am worried they are not being aggressive enough and her neurological symptoms wil remain. Should we see another kind of specialist or just stay with this treatment. They have not given her a diagnosis other then critical level B-12. Thank you
My B12 has been about 180 for the last time years. I am 60 now and always tired and foggy. Will B12 injections help me?
My neurologist just said my B12 level is a 7 very low he said I need to take the liquid 2 drops a week or I’ll be in a nursing home. What does he mean by that and how bad is 7 what could happen?
Well, let’s put it this way. If mid-level B12 is supposed to be between 200 & 900…and your’s is a 7! What do you think. Have no clue what my Mom’s B12 levels were but she ended up schizophrenic. Hearing voices, running off in the middle of the night down the road. Was not pretty. It was a B12 deficiency, plain and simple. She had to take shots every two weeks the rest of her life but she was fine. Runs in my family. I have taken b12 for years. Its a simple test, simple diagnosis and simple remedy.
Hi , I have had 3 babies all one after the other and was very sick and depressed through all 3 pregnancies but the worst was the 3rd pregnancy. When my baby was 3 days old I was given an antidepressant to take. I took that for 2 years. 5 weeks ago I slowly started to come off the antidepressant as I believed taking it was making me feel worse. After suffering from the most horrendous withdrawal symptoms from coming off it I went to a private GP begging for help. The first thing she done was take bloods to check my b12 levels.
The following day (last week) I went back for the results. The doctor said she was shocked that I was functioning at all because my levels were so low at 100. The doctor told me she’d only ever seen one other person with such low levels (19) and that lady was pregnant. I am now having B12 injections every second day for 2 weeks along with an oral b12 supplement each day. The GP thinks that my depression could have been from B12 deficiency (I have a few other symptoms from the deficiency also) but because my levels were never checked before now, we can only wait to see how things change as my levels go up. I feel so let down that a doctor knowing all my symptoms, would never have thought to check my b12 levels but instead put me on antidepressants.
Hello my serum vitamin b12 lrvels are 324 pg/ml and folate is 5/3ng/ml.
I have strong family history of PA and am suffering alot of symptoms mainly brain fig and eye disturbances that i thought were occular migranes. Can i request a therapeutic trial of injections on these levels?
About 5 years ago I visited a hormone clinic and received a MIC injection. I was told that it was just a bunch of B vitamins and that is was all natural.
Immediately after the shot I felt like I would vomit and I felt uncomfortably hot and dizzy. I thought I was going to pass out. I had to lay down for a few minutes until it passed. The nurse then asked me if I was allergic to Sulfa drugs. I guess there was more in that injection than just B vitamins. Since then I am very careful about what I put in my body. I would like to know if I can have a list of ingredients in your B12 injection before making a decision on whether or not to purchase.
Thank you very much.
There’s one ingredient: 100% pure methylcobalamin. No preservatives whatsoever. When you mix it, please use sterile 0.9% saline and not bacteriostatic water (which may contain benzyl alcohol).
Hi, I just read your book which is very interesting- thank you. I have recently been diagnosed with b12 deficiency (level 95) but on the NHS they will only give me one injection every 3 months. As I have neurological symptoms, I want to self-inject to help myself! THANKS. Your book has been a great help, it feels as though most doctors in the UK don’t know or care about b12, so it’s good to see that somebody does.
I discovered that what are deemed normal B12 levels here in the UK are would be deemed borderline deficient in Japan – which led the world in research as of 2012-14 – and UK levels are higher than those deemed “normal” in the USA. Most alarming is that the most common test for B12 – the first-line assay (blood tests) can return a false-positive as much as 35% of the time; this is not merely because the test is essentially useless but because many factors – some of which are mentioned here; such as folic acid levels – can interfere with test results. This means more involved tests are required to be certain – but here’s the real pig: most doctors will not consider more thorough (i.e. reliable tests) unless the first line tests indicate deficiency – even though those tests are essentially useless in most cases. In terms of actual usage, when I first started receiving injections, when it kicked in after about four or five days, I went from feeling like I was made of lead to feeling like I was flying; I had not had so much energy in years. Now that I’m getting back to normal levels my energy is rocketing again and my anxiety and depression are rapidly fading. DOCTORS ARE KILLING PEOPLE WITH THEIR IGNORANCE ABOUT B12 DEFICIENCY!
I was diagnosed with PA and atrophic gastritis 11 years ago. Was very unwell for over a year before, plagued with urinary infections, brain fog, abdominal pain etc and when finally tested my level was 75. I was immediately put on a loading dose over 2 weeks and then top IM B12 injections every 12 weeks thereafter, later reduced to 10 weekly. My most recent bloods showed a healthy level of 400. My GP now says I can no longer have the injections and must supplement by taking oral tables of 1000 mg daily, in the hope that I may absorb 1% of this dose. Having been so ill before being diagnosed, I am terrified of the consequences of this, particularly as I am a carer for my disabled elderly husband who is also being refused IM injections. I understand that every precaution has to be taken in the present circumstances of Covid 19, but I do feel that our lives and health are being put at risk by this decision. I am in the UK
Thank for your work to educate us. I am hopeful all you’ve enlightened me about may mean a diagnosis at last . I have ordered a kit from you 10 days back, I am in the USA, Colorado. Can your team advise me please, for when I might expect my package so I can plan? I *am* able to get a USA compounding pharmacy to make me methylcobalamin… it is just twice your price for only 5 shots!!! Thank you, and blessings on you and your team. I appreciate your courage. Warmly, Loraine.
Hello Regev, thank you for your wonder service you provide to give us disadvantaged humans the chance to be alive and exist. You are to be commended. Be rest assured the most high God will bless you for your good work. Sincerely, Ese Robles.
Wow, alot of info to digest! I was diagnosed with PA 40 years ago when I was 31. Have had Cyanocobalamine injections 1xmonth all this time. I am now 71. Have been getting pins & needles in my legs, have megaloastic anemia, on the low side of red blood cell count & white cell count as well. I have tried for years to get a Dr to RX for Methylcobalamine, but they all say there is no injectable Methyl. And then I found you 🙂 Thank you so much.
My 6 year old is on the spectrum. His biggest problem is speech. I have heard so often that parents have had success with their children with speech by doing the methyl one in shot forms (super tiny needle) in the butt at night while they sleep. Have you seen studies to support this?
I have MTHFR mutation that causes me not to be able to convert B12 in my body and was advised to take methylB12. Can you give me more information on this? Thank you.
Dear Karen,
Regev Elya’s site is excellent for B12 info and his supplement sounds very good. There are 2 other sites I like and use for info as well: Dr. Ben Lynch’s site: http://mthfr.net/ and the Phoenix rising site: https://phoenixrising.me/
Dr Lynch also has the gene mutations, and the gigantic phoenix rising site deals with the genetic mutations, chronic fatigue, and everything involving B12 and folate issues.
Methylcobalamin is not sufficient as a singular source of vitamin B12. Hydroxocobalamin and cyanocobalamin can both be split by the body into methylcobalamin and adenosylcobalamin. Methylcobalamin on the other hand is not converted into adenosylcobalamin. Deficiency of adenosylcobalamin disturbs carbohydrate, fat and amino-acid metabolism, and hence interferes with the formation of myelin. Thereby it is important to treat vitamin B12 deficiency with hydroxocobalamin or cyanocobalamin or a combination of adenosylcobalamin and methylcobalamin.
(from https://en.wikipedia.org/wiki/Methylcobalamin)
You should read this : https://www.ncbi.nlm.nih.gov/pubmed/25117994
It’s hard to glean much from just the abstract – I would need to read the whole article. Anyway, actually methylcobalamin that is ingested (either from foods or supplements) isn’t used directly as a cofactor. It is first converted by MMACHC (a gene providing instructions for metabolizing B12) into cob(II)alamin, which is then further converted into methyl&adenosylcobalamin for use as cofactors. That is, methyl B12 is first neutralized and then regenerated as either of the usable forms.
As a proof see this paper. The author studied 3 vegans with elevated uMMA levels and treated them with methylcobalamin (1,000mcg tablets, 2 times/day for 3 weeks). Two of the subjects’ uMMA levels normalized while the third one had his levels only slightly elevated (4.1mcg/mg creatinine while normal is <4.0). Elevated MMA levels indicate a deficiency in adenosylcobalamin (again, it acts as a cofactor for the conversion of methylmalonyl-coenzyme A to succinylcholine coenzyme A), so this indicates that the methylcobalamin was successfully converted to adenosylcobalamin for use in the MMA pathway.
And don't forget that many of the readers here have pernicious anemia. This is much more fatal then mere B12 deficiency, and those people often need as few conversion steps as possible so they absolutely need the native forms. They often have other co-morbidities like impairment of the methylation cycle, and that leaves them with extremely dangerous high levels of homocysteine. Methylcobalamin offers a methyl donor and is the most effective way of eliminating the homocysteine, thus addressing both diseases - PA & Hyperhomocysteinemia -- in one treatment.
Also, I can't support any research that purports the use of cyano B12. Who on earth would choose to put a non-natural cyanide compound in their body and deplete valuable methyl groups to detoxify it? It beggars belief!
In summary, one abstract on B12 deficiency does not overturn the massive weight of evidence that supports supplementation with bio-identical, native methylcobalamin, especially for pernicious anemia patients.
Don’t blindly believe everything you read. From the same Wikipedia:
“Except in rare cases, the human body has the ability to convert any form of B12 to an active form, by means of enzymatically removing certain prosthetic chemical groups from the cobalt atom, and replacing them with others.”
P.S Conversely, adenosylcobalamin can also be converted to methylcobalamin. The two forms simply interconvert.
INCREDIBLE info. Thank you so much. So MMACHC is exclusively responsible for everything B12-metabolism related?
My pleasure 🙂
Not exactly. The MMACHC contains information on how to process different forms of B12 to be converted to either Adenosyl or Methyl B12, but it interacts with MMADHC to actually transport that processed B12 to wherever they are needed: the mitochondria in the case of AdeCbl, and the cytoplasm (cell fluid) in the case of MeCbl. Then its finally converted and is ready to use.
“Who on earth would choose to put a non-natural cyanide compound in their body and deplete valuable methyl groups to detoxify it”
Apparently in the US, UCLA, Blue Cross and every other insurance company as its cheaper!
Thank you for all your information!
The way I understand it, nitrous oxide can render all forms of B12 inactive in the body, right? Would appreciate if you can explain. Thanks.
Yes, absolutely.
The cobalt in active B12 exists in a +1 state, cob(I)alamin. But before that state, it starts in inactive +3 and +2 oxidative states and is reduced to +1 in the body. Nitrous oxide is dangerous because it inactivates and oxidizes the +1 cobalamins back to their former +2 and +3 forms.
Dear Mr. Elya,
I would like to thank you for your comprehensive discourse on vitamin B12. I would like to add my story by saying that I myself have discovered this pseudo-accidentally. I’ve been craving for meat for the past few days and my mental capacity has gradually been becoming foggier and more forgetful over a year. I have suffered the same symptoms as immense tiredness as you have described, within the last few weeks despite getting at least 9 hours of sleep and it has impacted my academic performance drastically. I was lucky to have made the connection as I found out I was taking synthetic B12 from a “complete-food” powder (Huel, similar to Soylent), which of course contained B12 with the cyano-group attached and hypothesized that being the cause as I’ve been mostly vegan by consuming Huel as my main meal three times a day almost every day with the very occasional meat or cheese.
Furthermore, your academic articles make a strong argument. However, could this discourse be used to persuade food companies such as Huel, Soylent, Saturo, and so forth as well as supplement companies to change their ingredients? Additionally, would you say that such a case is occurring with other vitamins and their synthetic “equivalents”? I very well may forgo this powdered form of existence due to its scientifically unsound basis due to its new nature.
Indeed, I remember being much sharper and more spirited before devoting into semi-veganism. In a way, I feel that I have performed a great sin unto myself. I regret it deeply, and I will make it certain to spread the word. Once again, thank you for confirming my fears and for your devout research.
Kind Regards,
Ahmad Al-Kawari
I assume cyano B12 isn’t safe for pregnancy because of the cyanide, but what about the native forms (adenosylcobalamin and methylcobalamin)? Are they safe enough? And if so, could you point a maximal safe dose? Ive read that more than 6,000mcg is never prescribed, is it because of safety?
Vitamin B12 has an excellent tolerability and absolutely no known toxic overdose levels. It is water soluble, so anything you don’t need is excreted through your urine. There is no reason to believe methyl or adenosyl B12 wouldn’t be safe during pregnancy. 6,000mcg is the cap at some places because there is no advantage in administrating more. That’s A LOT of B12 in one dose, and no doubt much of it goes to waste. The key with B12 is little and often, you’ll get more benefit from frequent, much smaller amounts (dosages as low a few hundred mcg a day, every day) than infrequent, large doses (say 6,000mcg every week).
What is a safe amount of B12 for someone with kidney disease? Can too much B12 cause problems for someone with very mild CKD?
I’m a little confused with regard to the relationship between nitric oxide and B-12 efficacy. I am just about to start supplementing with a liquid Methyl product but I also have daily enhanced levels of nitric oxide (NO) from taking a l-citrulline/glutathione mixture to assist in workouts and recovery and also helps with blood pressure. The l-citrulline converts to l-arginine and then to NO. Will the NO interfere with the effectiveness of the B-12 or visa versa? Fantastic article by the way
It appears that 33%+ of the (elderly) population has a genetic mutation that prevents conversion from cyanocobalamin and folate to the methylcobalamin and methylfolate. I was tested for the MTHFR gene mutation, the results were positive for one copy of the C677T and A1298C mutation. As a result this may cause macrocytic anemia as tested in my regular lab works (a MCV larger than 100) and a low RBC count. What made me request the MTHFR gene mutation test is the fact that my plasma B12, folate and B6 levels (no or low absorption) have been largely elevated for more than 10 years along with elevated levels of my MCV and lowered levels of my RBC.
You may want to include this on the website.
Thank you, Pieter Verhoef
I have the MTHFR mutation (that causes me not to be able to convert B12 in my body) and was advised to take methyl B12!
Very informative website! Question – So, I uploaded my 23andMe raw data to NutraHacker and their recommendation, based on heterozygous mutation of the COMT genes, was to avoid methyl groups and substitute instead with hydrocobalamin. Thoughts? Also, is your product supplied in a powder form that could be applied topically with similar efficacy?
Big thx,
Chad
Hi, I have found your website very informative.
I am still confused with few aspects of the sickness and the doctor is very evasive.
The blood results show
IFAB positive and
Antiparietal Cell Antibody : REACTIVE TITRE 320 (screen 1:20) ,
B12 Total 207 pmol/L (162-811) ,
Active B12 27pmol/L (>35) ,
S.Fol 35.2 pmol/L (8.4-55)
I was just diagnosed with PA and I had an endoscopy which confirmed the diagnostic.
Microscopic Description of endoscopy:
The specimen consists of fragments of gastricbody-type mucosa with mild to moderate infiltrate of plasma cells and lymphocytes within the lamina propia. No active inflammation is present. SEVERE atrophy of specialized glands is also noted in association with patchy intestinal metaplasia, but there is no evidence of epithelial dysplasia or malignancy. No helicobacter-like organism are identified.
I receive B12 injections one per week for the first month or so. I have just received the first one.
I am concerned of the specialized glands. Are they going to start working at any point?
And the scariest part is the metaplasia. How is this going to be healed? If the immune deficiency continues to attach the lining of my stomach, will metaplasia get worse and ending up becoming cancerous? Will the diet help to fix the metaplasia or having B12 injections will heal it?
Any suggestions apart of B12 injections and diet? I am aware that I will be on B12 injections for the rest of my life (I am 49) but I want to know if all PA has metaplasia, can people live normal life with metaplasia without being healed, etc.
Thank you
I’ve had this problem for over a year and have been struggling. I’ve spent hundreds of dollars on pills and liquid b12. I went to a doctor and had a blood test done and they couldn’t find anything wrong with me. I spent money on tools to test for diabetes to see if that was it. It wasn’t.
The only reason I knew to take b12 was because one of my mother’s cancer doctors guessed that my symptoms seemed like a severe b12 deficiency.
I’ve been taking pills and drops for ages and haven’t ever fully healed. The Covid situation and my lack of insurance means I haven’t been able to get to another doctor. Not that they’d be able to actually help me anyways, given that apparently it’s only this kind of b12 that heals you. And only if you inject it.
It’s been incredibly miserable because the only thing that provides any real relief is eating beef liver, which took me 11 months to learn. I can also take lots of nutritional yeast but the healing is temporary and fades within hours. Even with the liver, I have to consume quite a lot of it to get any real long term benefits, and take vitamin D to counteract the massive amounts of vitamin A I’m taking in, along with hours spent in the sun everyday.
I eat a mostly meat diet now, and stuff like potato chips for potassium as anything else or anything that has even the smallest amounts of sugar in it, artificial or not, causes terrible reactions that leave numbness and mental effects. I’ve had issues with losing potassium from consuming so much b12. I haven’t found many vegetables that don’t leave me numb and depressed for hours after.
What’s especially bad is the memory loss and the apathy. At one point during this I reached a level of hopelessness and coldness inside that was indescribable. I intellectually knew I was deeply sad but I couldn’t even feel it. A part of that has stayed with me since then.
I once bought a package of b12 methyl powder which purported to be 1% b12 and 99% mannitol. Mannitol is one of the few fake sugars my body can actually tolerate, but it still causes some degree of numbness. I didn’t notice any real effects from taking it orally, but my skin did break out a lot.
If I’d known what I know now, I’d have tried your product way sooner. But how could I have? It was a fight just to learn anything about this condition and was a long series of trial and error to find anything that could help me.
I’ve taken every kind of b12 there is, to varying degrees of use. But still, any amount of sugar or excessive salts will push me right back down and make me worse off than I was before. I sat and gradually watched my mind slip away and the intelligence and creativity I was known for diminished. I can speak about these events now and I don’t feel anything about them, but it was overwhelmingly depressing as it happened.
Not to mention the incredible guilt at the thought that my desire to eat a piece of cake is responsible for doing irreparable harm to my body. I used to enjoy sodas, candies, and fast food such as Chinese takeout, but now the thought of it fills me with dread. Food used to be one of my favorite things about life, but now I hate it.
Even seasonings can make me react. I eat everything mostly bland. It’s the only time I can feel somewhat normal. Just blocks of ground beef cooked in the oven and then saved in the fridge to be heated up in the microwave when I get hungry.
Now I rarely even feel sad. Most of the time I feel nothing. I’ve noticed my patience has gotten shorter and shorter and I’ve withdrawn from many of the things I used to enjoy. I don’t have the energy anymore and I just don’t care. It’s difficult to even maintain a conversation with another person. I have no interest in what they’re saying and my attention frequently wanders. I can even forget things they said to me moments ago.
It’s a pity. I used to have a vast memory with real attention to details. I went from having a bucket to a tea cup.
I found your site when I was looking into b12 injections of the other kind. I found a cheap deal of an inferior type but then came upon your offer. It’s a bit of a pain to have to go looking for needles and saline solution, but what other choice do I have? There’s nothing else I can try. The free clinics in my area are all completely overworked given the coronavirus situation. And again, would I even be able to get the right kind of b12 from them? Probably not, given what I’ve read other people say.
I suppose it’ll take a good 21 days for the stuff to get here, but I’ll be injecting it daily. If it actually helps me, you’ll have a repeat customer.
Hi Elya,
I wanted to ask you how often i need to inject B12. I don’t have PA, but iron and B12 deficiency. So I’m planning on injecting 1000-1200mcg per dose, but not sure how often? Daily for the first week than 2-3 times a week?
Appreciate your insights.
Regards,
Polina
Hi Regev,
First of all thank you for your dedication to helping sufferers of vitamin B12 deficiency, something I am grateful for!
I’m starting to think I should have ordered a 3 month supply..
I have had type 1 Diabetes for nearly 20 years, I was diagnosed at 11 years old.. about 6 months ago I had a blood test confirming I was low in B12 however my doctor didn’t seem to associate my anxiety or nerve issues as related. I was also experiencing a sore tongue, pins and needles on my face, hands and feet. After receiving one B12 shot I didn’t feel any better so went to a second doctor who gave me 2 additional shots and tested me for PA. My test result was negative for this condition and I did feel somewhat better in the coming weeks plus I was taking methyl B12 sublingually in high dosages.
Felt pretty good for 3-4 months but in the recent month I’m feeling a sore tongue and burning hands again. So this time I’d like to try injecting myself! I’m hopeful this will help me! Would you recommend I inject daily for 3 months? And if so what could be a maintenance dose afterwards?
Many thanks
Stephanie
Hi Regev,
I am relatively new to this journey with B12! After years of mystery nerve pain associated with gastric distress, I diagnosed myself with PA. My doctors agree. Then, of course, I was on to learning about the complexities of the B12 injection world. Oh, my… I have ordered the first round of injections from you and am eagerly awaiting their arrival. Meanwhile, I wonder if you could tell me from where your methylcobalamin is sourced, as I understand there are different possibilities for this. Is it from animal products, and if so, can you tell me which ones? I would so appreciate this information. Meanwhile, I am looking forward to my first mailing and to trying out your injections. I am hoping that they will greatly assist in reversing and/or ameliorating the nerve pain I have experienced for quite some time. Again, thanks so much!!
Ruth
My active B12 levels are at very low end of scale which explains chronic strongly associated symptoms. However I can’t tolerate injectable replacement therapy owing to very low pain threshold, a common link with fibromyalgia. As this isn’t a viable option I have researched the various forms of B12 that might be taken orally, singly or in combination and have been left thoroughly confused.
What would be your recommendation as a solution to this or is there one? Methycobalamin seems to show great promise but is oral administration effective? If so best taken in combination with other forms? And if so in what dosages.
Hope you can help, been looking for an effective way forward for a while. I am 63, female and live in UK.
Thank you.
Hi,
I’ve been injecting pharmaceutical methylcobalamin for several years. It is prepared with sodium chloride and water. Even though I handle it extremely carefully, it’s a hit and miss. The shots degrade very quickly even if they only have been sitting in my fridge, protected from light. Only the first few shots in each box of ten gives me full relief.
Do you think that your dry B12 + saline would offer more stability? Or would I essentially have the same product once I had prepared the solution?
Also, can you prepare several shots at once and expect them to stay stable in the fridge? Grateful for honest feedback.
Hi, my mother, who has pernicious anemia, has been taking the synthetic form of B12 injections for about 30 years. My father vaguely recalls that at one time, the Dr. switched her from the Cyanocobalamin to Methylcobalamin but it didn’t work for her and so he switched her back to the Cyanocobalamin. Now that they no longer manufacture the synthetic form, my mother is now on the Methylcobalamin and is not doing well. Unfortunately, my mother’s original doctor is no longer alive and the current doctor doesn’t seem to have any answers. Would you know of any reason why she is not doing so well on the Methylcobalamin vs the Cyanocobalamin? Is it possible that there were other ingredients in the synthetic form that played a role in how how well she responded? Or, with the Methyocobalamin, are there differences in grades, purity, etc. that may affect the outcome. Any help you can offer, would be very much appreciated. Thank you so much for your time.
Hi Regev
As hydroxycobalamin injections isn’t really working at all. I know I have generic mutations along the transcobalamin 2 pathways… Its greatly reduced. Alongside repeated stomach infections and age I am clearly not absorbing b12 via intrinsic factor anymore. On top of this I am thallassaemia trait too. Microcytic… so all is against me and believe me I am just holding on. I had recent bloods done after taking so many methycobalamin b12 liquid drops and patches and my total B12 was 196. I know this is a useless number and yet my GP still did not want to know.
Once injecting active methyl cobalamin will my body convert what it needs to adenosyl cobalami too and hopefully methyl subcutaneously will have a far greater effect than hydroxy cobalamin.
You hear so many false news on the b12 help sites like you need injectable adenosylcobalamin as well as methyl. Is thus true?or can my body get and generate adenosyl from methyl. Besides methyl is active. Hydroxy needs conversion and as I mentioned my trans2 pathways greatly reduced alongside IF.
Is subcutaneous as good as intramuscular?
I feel so neglected by the medical profession even though I am now bed ridden and my heart beats hard to get blood round to deliver oxygen.
Thank you.
I am at the moment slowly cleaning my gut plus I do have leaky gut and leaky blood brain barrier too. I mean avoid pharma like the plague….. that’s what destroyed my gut. Western medicine… antibiotics and corticosteroids nsaids etc.
I even have to split an over the counter antihistamine like loratadine 10mg into four and take them 10 mins apart to avoid the head ache.
Hydroxy shots did not give me any headaches but that does not cross the blood brain barrier.
Should I start on half a dose of methyl at first to see.
Kindest regards and apologies for all the questions
Hi Regev 🙂
Just want to let you know: the seriously magical Methyl-b12 arrived yesterday, thank you!
I added in the 10ml sterile-water, and I know the recommended daily dose is 0.3ml (1.2mg).
Although it might be wasteful (over-saturation) I happily began with a big dose of 2ml (8mg).
People who haven’t studied about b-12 deficiency might assume this is “placebo effect”, but:
I feel confident my first dose yesterday has already resulted in me having more energy today!
By the way, here is a good Dutch summary page showing that even 10 grams is perfectly safe.
https://stichtingb12tekort.nl/wetenschap/stichting-b12-tekort-artikelen/english/treatment-with-high-dose-vitamin-b12-been-shown-to-be-safe-for-more-than-50-years/ (Ctrl+F: 10 grams) (plus, there are 12 references at the bottom of the page for those who need further evidence of the safety of b12: 100% non-toxic, thus zero-chance-of-overdose, just like eating Cannabis.)
Anyway, from today I will take the normal recommended daily dose of 0.3ml (1.2mg), and I will let you know how it goes!
Much Gratitude to you for choosing a business which helps people become healthier and happier. Thanks again Regev!
Sincerely,
I am in a quandary: My B12 blood test came in at 231 on a scale of 200 – 1000mL. . I have many symptoms of anemia and my mother was treated for Pernicious Anemia lifelong. In the past year I have been experiencing major weakness in legs and arms, major issues in balance and walking, .loss of appetite, consistent cold hands & feet, and feeling of nausea instead of hunger. I take Nexium for digestive issues.
I am a healthy 77 years old. My primary care doctor, of many years, has informed me that my B12 blood test was “normal”. He’s the professional ,and I respect that, Please advise. Thank you.
hello there,
I have hashimoto’s thyroid disease and I have found that the b12 shots help me tremendously and I purchase your book but I would like to know if there is a book in Spanish, I would like to give it to my parents to read.
thanks you
Dear Regev,
My son was diagnosed with autism when he was 2 years old he is 5 years now. We have started his biomedical treatment and so far there are some improvements. He is still non-verbal, he was recommended for MB12 Shots. So i was searching for feasible option on internet and found your website. However he is taking the oral spray for now but i know it wont help him that way. I am highly obliged to find something which can help my son and many more others who find difficulty to get those prescribed MB12 Injections which requires every time visit to the clinic and for us it is really challenging.
Thanking you in anticipations,
Regards
Nisha
Hey Regev, everything arrived perfectly in great shape. I began injecting 3 weeks ago tomorrow. Honestly, today is the best I have felt. It has been a terrible road dealing with doctors. I have been symptomatic (tingling, numbness, weak muscles, terrible short term memory, dizziness, hair loss, and finally digestive issues and tachycardia). I felt as though I was dying a slow horrible death. In 2007 I was diagnosed with mononucleosis and B12 deficiency. I lived in Florida at that time. My doctor started giving me B12 injections immediately. Eventually I healed from the mononucleosis and felt better with the weekly b12 injections. Then I moved to Cleveland Ohio and shortly after I started having “ pins and needles”. My doctor told me that the pins and needles were due to taking half of one Benedryl each night. I stopped taking the Benedryl but the “pins and needles” continued. That was eight years ago. Slowly I began to endure more symptoms. Now I have been living in Mississippi for 4 years and all of these symptoms that I mentioned above hit me hard two years ago. I have seen 11 doctors and the only b12 test they will give me is the serum. I have requested a methylmalonic and homocysteine test. They tell me they do not do those tests. I requested a test for intrinsic factor or pernicious anaemia but they insist the serum test is sufficient. My serum tests were all over the place from low to high therefore I do not feel that they were accurate. My Grandfather died in 1986 of a “blood disorder”. This is what his doctor called it. He had a lot of my symptoms. He would tell me how is legs just couldn’t carry him anymore. I asked his doctor if he had leukemia and he told me no. He could never give the blood disorder a name. They gave him blood transfusions every couple of months. Then they gradually increased to three/week. My Grandfather withered away. I wish I knew then what I know now. I was just 20 years old back then. I fear he and I are one in the same. I have never been so frustrated in all of my life as I am today. The only thing one of my doctors discovered is that I am D deficient. They discovered that in my basic CBC bloodwork. They have done MRIS, colonoscopy and endoscopy, and nerve testing which were all fine. One doctor thinks I have corpal tunnel so he injected my wrists with steroids. Another doctor of the 11 doctors offered me cymbalta for pain. Even the pharmacist said Cymbalta is not used to treat pain! This is just a glimpse of what I have been up against. I began doing my own research convinced I was probably going to die if I didn’t get some answers and help quickly. That’s when I found you Regev!!! And I thank God that I did! I am finally beginning to feel a little relief. My hands, lower arms, and lower legs are getting better everyday. I’m not constantly feeling like an electronic circuit board anymore. My ankles are not as weak as they were. I feel as though my muscles are coming back to me slowly each day. The tachycardia seems to have stopped. I’m praying that I will eventually feel healthy again. Maybe my digestive issues will get better over time?.. I just want you to know that I probably would have withered away just like my Grandpa if it weren’t for you Regev. Please don’t ever stop providing this life saving vitamin!!! I can not imagine how many people out there who are just like me? I am not sure if doctors are undereducated or if “big pharma “ has something to do with the lack of treatment for people like me? Please forgive me for “bending your ear”. I just want you to know how desperate I became. Again… Thank you from the bottom of my heart… you saved my life!!!
Hi Regev. I’m so happy I’ve found a company I can order injectable methyl-B12 from at an affordable price. I have suffered from fatigue off and on for decades, most likely autoimmune in origin (dysautonomia has been diagnosed in just about everyone on my mother’s side of the family who has had the testing done .. I have not had the testing done, but I’ve had many of the symptoms for, again, decades). I have achalasia, which so far is still a “mystery” condition, but the most extensive study I’ve found seems to point to it being due to a genetic abnormality and/or autoimmune (and I still think there may be some connection to the allergy shots I got for about three years – the early symptoms of achalasia started after I’d been getting allergy shots for about three years .. maybe coincidence, but maybe not). A group in Germany did a study on about 1,500 achalasia patients, and if I remember correctly, in every one of the achalasia patients (and not in any of the control subjects in the study), they found a genetic abnormality in the same area where there’s an abnormality in MS patients. That makes sense .. in achalasia, the nerves of the esophagus are affected rather than the CNS, so I suppose I can be grateful that it’s achalasia and not MS. In case you’re not familiar with achalasia, what that basically means is that the peristaltic action of the esophagus has ceased to function and that the lower esophageal sphincter (or LES, the opening into the stomach) does not relax to allow food to pass through, so food most of the time sits in the esophagus for prolonged periods of time. Esophageal mucus builds up (attempting to move the irritating food into the stomach or pad the esophagus from the irritating food or liquid that should not be sitting there), pressure builds up, and it usually results in regurgitation, so lots of episodes of regurgitation, whether it’s food or liquid one is trying to get into one’s stomach. I go through this every single time I attempt to eat (since around 2002, when it got really bad and has only gotten worse), and the list of foods I now even attempt to eat has gotten very small. The medical world offers nothing that is acceptable to me, and definitely does not offer any kind of cure since they don’t even know what causes it. The medical world’s answer is surgery (Heller’s myotomy, generally) to cut the muscles of the lower esophagus and esophageal sphincter – no thank you – or esophageal dilatation, which is temporary, has to be repeated, and carries risks of tearing or rupturing the esophagus, and they also can do botox injections into the LES. I haven’t had medical insurance in many years, but even if I did, I wouldn’t submit to any of those treatments. I had my esophagus dilated in 2000 or 2001, and didn’t notice any difference. This all started for me in the mid ’90s with esophageal spasms (I thought I was having panic attacks out of the blue), which then developed into trouble swallowing food, and that has only worsened over the years. I mainly eat a vegetarian diet (again, even though I’ve always preferred more veggies to meat, but I did used to eat meat regularly – but now rarely try because of the achalasia preventing me from being able to eat and digest meats for the most part, although I can sometimes eat fish, sometimes eat some chicken liver, but mainly I eat a whole lot of avocados because they slide down into my belly mostly without trouble, and I add sunflower seeds, sesame seeds, sometimes almond slivers or other nuts, sometimes some shredded asiago, and I eat a lot of bulghur wheat, quinoa, that kind of stuff. Rice and pasta are always a no-go, will come right back up, as does anything but very, very thin, crisply toasted bread (so I instead eat pita chips or bagel chips and mostly skip bread .. sadly). And I eat quite a lot of homemade pureed veggie soups (but even have trouble with the starchier veggies, like potatoes, which you’d think would go down just fine, but this is a very strange condition, and I can never count on anything going down – but avocados are almost always reliable, so I eat avocado just about every day). Just because something is soft or mushy or liquid doesn’t mean the LES will open and let it into the stomach, and lots of things, even if they do make it into the stomach, might sit there for 12 or more hours and not digest (which means they will eventually come back up).
I have found great help in keeping myself feeling well and healthy through learning how to use different supplements therapeutically and have gotten great results using high-dose vitamin C, niacin (fantastic for depression and energy, along with keeping the gums tight around the teeth, and, of course, maintaining the nervous system), and other supplements. Of course, I do have trouble getting some of those supplements down because of the achalasia, so have to be creative sometimes (like opening capsules and dumping the powder under my tongue, and being very careful with the acidic vitamins like C and niacin, which can sometimes set off a massive stomach rebellion .. I would love to be able to inject those as well, but haven’t really looked into it yet). I’ve been taking a sublingual methyl-B12 for several years now (5,000 mcg, usually one a day but sometimes two), and most of the time, that is enough, but with all the additional stress of this past year, I’ve ended up having several bouts of what is either shingles or CFS, and this last one has really knocked me flat for about a month now. I had felt certain that it was shingles each time, despite the fact that I don’t get a rash but instead get a strange tingling/stinging effect on the skin (along with it looking sunburned and sort of “puckered” in the affected area), because not everyone necessarily gets a rash, and I have had all the other symptoms each time. I still believe that’s probably what it’s been since I have had it quite a few times over the last 19 years (had chickenpox at 33, and then got what was definitely shingles for the first time at 38, so I know what shingles feels like), but I was reading a study recently where they believe that there’s a connection between shingles and CFS, and that made me wonder. I mean, it makes sense that they would be connected. I think lots of conditions result in chronic fatigue, so that really doesn’t even matter so much except that when I read about a skin condition connected with CFS called paresthesia, that made me wonder, hmm, is this shingles I’m getting or is this CFS unconnected to shingles? Again, doesn’t really matter .. what matters more is managing it because this last episode, again, has left me basically too fatigued to even feel like doing any of my normal activities since late January (yeah, I let our presidential election really stress me out for too many months … and I knew it was probably going to knock me down at some point – so the shingles suddenly zapping me wasn’t a surprise, although it was a disgusting development). I’ve been an avid cyclist for nearly 20 years, ride as many days as I can, stay very active normally, work long hours from home, have a lot of interests that I enjoy, usually a very active, energetic person – until I get knocked down, which can end up lasting for weeks, and that’s been happening way too frequently over the last year.
Well, this last time, with it lasting so long, I decided to try doubling, tripling, quadrupling my sublingual methyl-B12, and that was helping as far as bringing my energy back (I also added benfotiamine to my daily supplement regime, and am working my way up to a higher dose, and that is helping), but I started having lower abdominal cramping that started with the extra sublingual methyl-B12, unrelated to any food I was eating. I did research and read that a higher dose of sublingual methyl-B12 can cause GI cramping. I almost never have GI-related cramping (I have enough trouble just getting nutrition into myself, so I’m very thankful that I basically never have lower GI issues!!). And then I started constantly feeling like I was going to faint (orthostatic syncope) unless I was laying down or in a reclined position. So after several weeks of taking approximately 15,000 mcg of sublingual methyl-B12, I skipped taking any for a day or so, and now I’m back to just taking 5,000 mcg once a day (and have not had cramping or orthostatic syncope since then, so I think that was the culprit).
I feel like I need more B12 than just the 5,000 mcg, since I couldn’t bounce back from the shingles CFS episode for so long, and I’d hoped my system would get used to 15,000 mcg of sublingual methyl-B12, but that didn’t feel like it was going to happen and just couldn’t tolerate the lower GI pain and orthostatic syncope any longer and sort of defeated the purpose if I couldn’t walk around without feeling like I was going to faint. I have no idea if I have pernicious anemia or not. I do know that I cannot skip my B12 supplement or I get into trouble real fast, and I’ve always wanted to try injections, but haven’t been able to afford it, so I’m eager to try this and see if it helps. I miss my bicycle .. it’s been a month since I rode (thankfully this latest episode coincided with a lot of very cold, nasty weather .. but now the weather has gotten much warmer and more sunshiny again!).
And I’m sure I’ve filled you in way more than what you wanted or have time for, so I’ll stop here. ;-D
Thank you!
Becky
Hi Regev, I began injections early February after receiving the first vial. Noticed a subtle difference immediately!
I used the first shot yesterday. I’ll go for the full 90 days of injections and will order more when I’m close to running out, accounting for the shipping times.
How quickly does the b12 degrade when exposed to light? I’m curious how fast I need to inject the needle once it’s drawn with fluid. I took about 2 minutes to line up and finish the first injection. Did that have any significant effect on the supplement?
Hi Jeff,
There is no straightforward answer I’m afraid.
I’ve attached some research articles for you to have a read:
Time-Resolved Spectroscopic Studies of B12Coenzymes: A Comparison of the Primary Photolysis Mechanism in Methyl-,Ethyl-,n-Propyl-, and 5′-Deoxyadenosylcobalamin
The Photolysis of Methylcobalamin
Photolytic Properties of Cobalamins: A Theoretical Perspective
Mechanism of Co−C Bond Photolysis in Methylcobalamin: Influence of Axial Base
Photolytic Properties of Antivitamins B12
I love it! i must buy more when i’ve saved up ! i feel 110% better already. THANK YOU!!!
Hi Regev,
I am excited about the possibilities of self injecting with this form of B12.
I was recently diagnosed with Pernicious Anemia after many years of weird neurological symptoms. I seriously thought I had MS for 24 years! It was only after connecting with a Functional Medical Doctor that ran a variety of tests not common to regular MDs that we zeroed in on what was going on. I tested positive for Lyme Disease as well as Black Mold Exposure. My RDW, MCV & MCH levels were just slightly out of whack and my homocysteine was elevated. I also tested positive on an Intrinsic Factor Antibody test. My main complaints were incredible numbness and tingling in my feet. This past year I could no longer do even 5 minutes on my Bowflex exercise machine and had virtually zero stamina. This was the most upsetting symptom as I have always been able to maintain some sort of exercise program.
As you have heard from many of your clients most MDs here in the states are only willing (or able) to prescribe B12 shots spaced far apart. I live in a rural part of Northern CA so it is not practical for me to travel to an MD as often as needed even if I could find one that was willing.
I spent some time on Amazon trying to find the Sterile Saline (NaCl 0.9%) that you recommend but every product I clicked on states “Not for Injection”. So…….do you have a recommendation of where to find a suitable saline? It also looks like I might need an Rx for syringes? If not….I could also use a source for these if you have one.
Thanks so much!
Denise
Thanks so much! I’m seeing some solid results in only a month since my last shipment. Injecting daily for the time being and then will slowly dial it back to every other day. A lot less pain in my hands and arms when I sleep — big difference. Thx
Thanks so much for the info!! I look forward to getting once again quality b12. My story started about 6 years ago when for years I had been telling my doctor that I was always so tired. Once they checked my b12 they discovered why. First I tried vitamins, then drops and nothing was working. My numbers wouldn’t go over 275.
Finally I started Injections, daily at first then weekly, then monthly, but was honestly still very fatigued and my numbers never could stay over 600. They did check me for pernicious anemia and I do not have that. But i have come to learn that many of my family members are also b12 deficient.
Meanwhile I had an endoscopy and was found to have Barrett’s esophagus and somehow that means I’m less likely to absorb the b12 and would be dependent on injections forever. I also have psoriatic arthritis and my rheumatologist wants me taking b12 as well.
Then one day a few years ago I was visiting my hormone specialist and while I was there we were discussing my b12 issues and I mentioned I was due for my shot, and she said she could give it to me. I noticed the vial said methylcobalamin and knew about the different types but for some reason didn’t realize this applied to the injectable type (clearly I’m not a scientist). Immediately I felt so much better with this type of b12 and began searching for a way to get this. Eventually I found a pharmacy here in california that could ship me the preloaded syringes on dry ice. This has been great but now they can no longer do this because of the new restrictions. Earlier in the year I got shipped to me methylcobalamin b12 but it doesn”t seem to be working and my fatigue is coming back. Supposedly it is shelf stable, but i honestly think maybe I was scammed and this is just crap that I am injecting. I’m having my blood drawn tomorrow so I guess I will see what is going on with my numbers.
Meanwhile I look forward to my shipment from you.
Regards,
Amy
Hi there!
I’m in the Pernicious Anemia camp. It took me a long time to be properly diagnosed and treated. As I result, I have some neurological damage along with the classic fatigue. Such a bummer! I have been self injecting with methylcobalamin that I buy from a local naturopath which is very expensive.
I have a question. I noticed on your website that you were using saline solution that looked like it was in an eye drop bottle. Is 0.9 sterile saline for eyes acceptable?
I’m so happy to have found your website.
Thanks,
Connie
Aloha! I am 63 years old and live on Big Island, HI. I have, over the past 10 years, been battling breast cancer. I refused conventional treatment and embarked on a course of trying just about every anti cancer protocol I could find. In the course of this, I also went on the vegan diet for over a year and became severely B12 deficient, lost my ability to function mentally and physically and developed severe allergies to just about every thing. I broke out in hives all over my body just from waking up. It got so bad that I could no longer eat or drink anything without a severe reaction and had to take benadryl to survive.
I have a background in biochemistry, but due to my brain having slowed down so drastically, it took me 3 months to figure out what was going on what should have taken me no more than 3 hours. I finally realized that my methylation processes were severely impaired and I ate a dozen eggs from my own chickens that day, and never had a hive again. Well, I realized I had become severely B12 deficient. At the time, I used lozenges to address this and literally used an entire bottle in one day. I got some transdermal patches and used those quite successfully for some years. Then my daughter sent me some methyl cobalamin shots and that was a lot more effective. I also started to treat my husband with B12….he has been a life long alcoholic, getting much better, but I know that B12 deficiency is an issue with him. And day before yesterday, a friend of mine told me how her husband, who had just had a heart bypass operation, was super pale and super angry all the time. I had noticed that B12 was very effective in reducing anger issues, especially in men. So I figured he was probably super anemic, was not eating and needed to build his blood back up. So I searched for a way to get injectable methyl cobalamin online. I have a farm and am quite competent in giving injections to my livestock. I even tried to get livestock methyl cobalamin, because I do have situations where B12 and iron injections become necessary. But a prescription was needed even for that!
Anyhow, I found your website, searched some more, and came back to your website. I am very grateful that you are making this available. I will probably buy some more in the future. I will be sharing this with my friend to hopefully help her husband recover. And also for my husband, as well as myself.
I have a question for you: I was very successful in combating my estrogen driven cancer with bio identical progesterone usp….micronized powder compounded in coconut oil and applied topically at a dose of 1200 mg per day, therapeutically, which shrunk my tumors rapidly. Then big pharma caused the government to come up with intolerable restrictions for compounding pharmacies and I was no longer able to procure it. I weaned myself down and went almost a year without. Well, my cancer has come back with a vengeance and I found a compounding pharmacy, but they refused to compound it with coconut oil, using some water based cream instead which smells and feels artificial and not beneficial for my healing. They also charge 3 times as much which means I cannot afford it. I am looking for a reliable source to purchase the micronized progesterone powder usp so I can compound it myself. Do you by any chance know of any possible source where I could purchase some?
Thank you in advance for your kind reply! Sending much love!
Christine
Hi Regev!
The kit arrived today!!! I am just SO anxious to get started and get some relief.
On another note……do you have any references for Lyme Disease and B12. A Western Blot test that I took showed positive for Borrelia Bergdorferi. I know some of the symptoms of B12 deficiency and Lyme can overlap. I will be taking another Lyme test as further confirmation before proceeding with any antibiotic protocol. I also want to give the B12 treatments plenty of time to take effect before I do anything else.
In the future I would be willing to pay more for shipping of future kits if that option is available…..such as FedEx…….just let me know.
I hope all is well with you!
I have pernicious anemia and thank you for the excellent diet suggestions, with you providing many explanations about all those foods I couldn’t eat as New Mexico doctors told me it was all in my head, the same doctors who were not HEARING me tell them there was “something” about me and B vitamins and ignoring my classic P.A. symptoms, even as I grew so weak I couldn’t walk!
Hello,
I have a question I’m hoping you’ll be kind enough to answer. I did order from you & I’m awaiting for my product. In the meantime I badly need some B 12 to get me started as this is new for me. There was a store in the mall in the US named The B 12 store and I bought a package of 8 shots hoping it would tie me over for a week. The syringes were tiny & only had 0.25 in it and she said it was for a weekly shot. I told her I need 1 ml as I know that’s what I will be taking when I get your product. She put it in a different syringe for me that was measured to 1 ml so I didn’t have to stick myself more than once at a time. It actually only came up to 2 shots that way. I’m having a lot of irritability today & when I got home I had a thought that I wonder if Methylcobolamin is always the same concentration or if the smaller amount would of been enough? I was so irritated at myself for not thinking of that when I was there. I’m not worried about over dosing but wanna make sure I take enough. Do you have any thoughts on this? I know it might be a foolish question.
Jessica
It was very nice to get your email. Also perfect timing as last night was the first night I had slept through in 5 months. I had walked into a ER and said “I am very sick please help me.” I weighed 250 pounds and had lost 100 pounds in 5 months or less, unintentionally and was dx as severely malnutritioned, severely calorie deprived and anemic. I was not in pain, rather severely fatigued. Fatigued as I am using it means sleep and rest does not affect fatigue.
Part of the reason I had not seeked medical help is after a half of a century of asking for help I decided if whatever was wrong was going to be solved I would have to do it myself. I am a 65 year old male. I have been B12 deprived my whole life. It was on a continuum with it being most acute in the winter both from my winter diet as a child and winters are hard on the body. I had been dx with a low red blood cell count often and told it was a sign of infection as my white cell blood count was high.
I was in the hospital for 5 days and they released me. I did not leave as I was too fatigued to function. It had been 5 days of tests for which I had to fast and I had my gallbladder removed as it had filled with sludge due to the rapid weight loss. I had to fast for the gallbladder operation. I lost a pound a day while in the hospital. I had been given two blood transfusions back to back.
I understand now what happened is my attending physician was not a hospital physician and was just winging it and filling in for the doctor who was to become my attending physician. After the second day the normal attending physician took over. Best described as incompotent and arrogant, not a good combination. He wishes he was a dick but will always be just a dink.
i was experiencing severe neurological symptoms which is still not dx as the staff made the incorrect assumption that what was happening is i was experiencing mental illness which was not the case. I do experience PTSD and that was on my chart.
I was then turned over to a nurse who was acting as a physician and is labeled PCP. She simply ran the computer program the incompotent doctor had decided was the program to use. Which was a series of cobalamin injections once a week for 7 weeks, folic acid and cobalamin tablets. Problem solved and is still the only treatment that has been prescribed.
During the series of injections I experienced severe peripheral neuropathy on a bell curve the pain peaking about halfway between shots. Then the shots were stopped which i was not told was the plan. The pain intensified when the shots were stopped.
I had experienced peripheral neuropathy my whole life as was used to it, I thought it was normal. I would do stretching, exercise and soaking my feet as part of my life never knowing it was not normal.
I expect that what happened is the stress of the hospital stay and age intensified the pain to the point it was not manageable in my fatigued state.
Although I read at the college level when I was 11, due to the undiagnosed neurological symptoms I could not read and comprehend. I read my chart which is available on a patient portal and knew something was wrong. OK I knew it was a cluster fuck.
After release from the hospital two and a half months later with the injections and the supplements I was able to think a little bit better and ordered “Could it be B12” I could not read it at the time and then bought your book as it was shorter. It is about a three quarter of an hour read for me now, it took me a week or more to get through it. I had passed it over as the blurb on amazon said something to the effect “Read this book and you will know more than most physicians about B12 deficiency” and thought that is foolish. I had no idea the standard was so low.
Note: i had been given a probable dx of pernicious anemia by a physician who had done a due to a endoscopy while I was in the hospital. I went with that was most likely and it has since been confirmed with an intrinsic factor test. 5 months later.
Note: The only two flaws I found with your book were it stated medicine has a complete understanding of the human body and I did not buy into the explanation of metholcobolonin. Noit
I hired a consultant from England named Tracey and found a supplier of Cyanocobalamin from British Columbia and reluctantly and gradually started injections and weaning off the oral supplements. Understand I was still experiencing neurological symptoms or as I called it my brain was not on. Not saying you were incorrect the logic did not seem correct to me.
So I injected 30 ml of cyanocobalamin over time settling on .5 ml everyday and have greatly improved. I am starting the methylcobalamin injections today at .5 ml every day and taking 1MG of folic acid until symptoms completely disappear. Hoping it is not just a case of they stop improving. Once the symptoms disappear which will be when that happens and no time line I will regroup.
I am still looking for a PCP or physician so I am not treating myself. I do not think self-treatment is a good idea. It is the best option I have. My PCP actually told me that my B12 level was 150 when in fact it was <150 and not detectable. She is a fountain of misinformation about B12 and anemia in general. There is no reason to meet with her and I am not scheduled to see her for 4 months. When i do meet with her i will gift her your book and say "if you read this you will not know as much as I do about B12 deficiency, it should reduce the risk of mistreatment resulting in neurological damage for those you treat and if you read closely you can prevent suffering for those you are have treated or will treat in the future.
So this is all caused by trauma which is too complex to address in an email. I direct you to Ellen Lacters website for more information as it is the best i can do. https://endritualabuse.org/.
On February 3rd a month after my release from the hospital I came up out of my brain fog and made a life decision that no matter what happened I was not going to say to myself. "I wish I had put more effort into preventing permanent neurological damage and that has been my primary focus since that date. It has been hard.
Note: Although the literature written by those that successfully treat B12 deficiency emphasizes the need for treatment to prevent permanent neurological damage I feel the error is made in not emphasizing it has to be correct treatment. Guessing there is a blind spot and the assumption that if the B12 deficiency is diagnosed then correct treatment will follow. It also seems to me that the urgency of treatment is based on the time of DX and not onset which without a miss-DX could still be months and months.
It was good for me to write this to someone who understands it is not only possible but probable. Thank you for the information of the 90 day red blood cell cycle.
I do have some questions which I will ask when my brain is on. I apologize for the chaotic writing, it is how my brain is functioning right now.
Thank you for your work!
Michael
A surgeon removed my secum during a surgery, said is was diseased. I am 53 in two days and a stroke survivor. How do I know which test my doctor is using test my B12 levels and/or which type of injection I am getting each month. Blood work form 2 days ago showed 537 and they say that is acceptable, I don’t think so because I have noticed memory fog, some days more severe than others. Should I be alarmed?? But yet total Cholesteral was 206 and she wants to put me on meds for that. HDL was 45 LDL 132 Tri was 146. Why not encourage diet and exercise first before pushing those meds and more B12? If I felt better maybe I could be more physical, mind you, we farm. Thank you in advance for any personal response I could get.
Hi Regev
I hope you are well.
After 3 months as you said I clawed back to very nearly normal and was up and about doing DIY, walking,going for drives etc and generally feeling good. I was back finally!
My GP ordered some bloods after I told them the ordeal i was going through. There was nothing wrong with my results apart from very elevated B12,due to SI.
previous bloods showed low B12 despite eating meat every day.
So all the staff told me to stop SI.
I took their advice and within two/three weeks I was flat on my back again with all the same symptoms….raised bpm, fatigue, breathlessness, no appetite,weightloss etc but not quite as bad but very badstill unable to function normally. I hate it..
I am amazed at the rapid decline.
Is this normal?
Kindest regards
Jeff.
I was looking for this for a while. I was only on your website for 5 minutes before I placed my order. You seem like a great expert. Thanks for making this great product available to the world.
Greg
Hi Regev!
Yes thank you so much I received the order and instructions. I got accepted into a geneticist’s office at Children’s Hospital of Philadelphia on June 8th and they will likely want me to not be on any supplements at the time of the appointment so I’m holding off on starting until after that. I don’t have PA but it’s very likely that I have a genetic issue with processing vitamin B12 and breaking it down into the methyl and adenosylcobalamin forms (my mom and I both have constantly elevated methylmalonic acid and symptoms of B12 deficiency despite normal serum B12 levels). Dr. Auwerda, a hematologist at the B12 Kliniek in Amsterdam, recommended that I inject with hydroxocobalamin and methylcobalamin once a week for a while and finding your methylcobalamin online was a lifesaver! Hoping the geneticist will write me an Rx for hydroxocobalamin so I can begin the treatments. Right now, I have your B12 stored in a dark cool area and I won’t mix it with the saline until I’m ready to begin injecting.
I will let you know how it goes and if I have any questions!
Thanks,
Erin
Your site hit so many point on symptoms that doctors dismissed and that , therefore, didn’t know related to b12 and my diagnosed pernicious anemia which is why I jumped on it. Particularly the aching arms and muscle spasms. Of course tired and weak accompanied w severe depression. Appreciate your support, always getting back to me with factual enlightenment.
Your B12 shots are definitely working!!! Thank you so much so glad I found you!
Do you know what a good maintenance dose is?
I don’t have a question, but a COMMENT. In your advice to patients, you seem to have the ASSUMPTION of some competency among doctors. For years, as my neurological symptoms, digestive issues and fatigue worsened, I kept telling doctors–or TRYING TO–that there seemed to be something weird go on with me and B vitamins, because if I’d supplement with B complex (though I had to be careful or it’d overload my system and give me problems.), I’d feel better . Their answers AS I GREW EVER SICKER? They’d sit and look stupid, bored or “Oh, you must be working the system,” because by that time I was on prescription pain meds to be able to stand to stay in my own body. Of note, these doctors included THE FAMOUS CLEVELAND CLINIC where I thought I had gone for a whole new investigation of WHY I was ill. Instead, they tried to put me into a special drug-treatment program. Of note, while there NO BLOOD TESTS were done except a routine blood chemistry! (I later filed a grievance against ALL doctors involved and they were sanctioned, but fat lot of good that did me!) That I was diagnosed–even as I was so weak and neurologically compromised that I could hardly walk–was because, WHILE TOO WEAK TO GET OFF THE SOFA, I was watching a PBS program exploring Mary Todd Lincoln’s pernicious anemia and when they listed the symptoms, I screamed to my husband, “Those are my symptoms!” We SPECIFICALLY DEMANDED tests, the next day, (by a reluctant doctor) for intrinsic-factor antibodies, although by that time, my B-12 levels were through the basement. DO NOT ASSUME OR IMPLY ANY COMPETENCY IN DOCTORS AS THAT REQUIRES ENGAGEMENT, SCIENTIFIC THINKING AND OPEN MINDS! Doctors today–in contrast to the past–have NO ability to do diagnostics, want to treat only what MOST PEOPLE HAVE and those patients who suspect P.A. need to know that, including that if a doctor says their B levels in blood tests are normal that doesn’t mean jack because neurological damage can be happening even as normal B-12 shows in the blood!
Hi Regev,
I was told over 30 years ago that I would have to take B12 shots for the rest of my life because of very low intrinsic factor. I have done so, but with cyanocobalamin which was originally prescribed. Over the past few years I have not kept up with the quantity I should have, which was originally 2 cc, 2 – 3x week. Injecting intramuscularly is not pleasant. Gradually, I moved it to 1x a week and even less… I haven’t been testing regularly for many years. I’ve been buying it and the syringes from sources other than the doctor’s office.
Recently, I started working with a naturopath who could tell I was low from a recent hair mineral test, not bloodwork. I’m not sure how he did that. He has had me on quick dissolve daily B12 orally and I was doing shots about 2-3x/month. Months ago, I had told him that I needed the shots and at least sublingual, if it was oral, but I wasn’t insistent enough. I wish sublingual would be enough for me, but I’ve never truly tested it alone. I was afraid to.
Anyway, I have been dealing with various neurological problems over the years and that comment woke me up to the necessity of resuming frequent shots again. I needed to re-order and I decided to look for methylcobalamin. Some years ago, I had gotten a prescription for it from an online doctor, but I only took the small amount I got and then went back to cyano because the methyl was quite expensive.
I found you while looking for another source.
I’ve never used the diabetic needles or injected anywhere except the hips.
The same doctor who originally prescribed B12 for me found that I didn’t utilize B6 properly either. Nowadays, we know that’s part of MTHFR. I really should be taking pyridoxal B5 as well. Writing this to you is helping me to decide to do that, as well.
Thanks!
Mona
Hi! It hasn’t been 3 weeks since I ordered the methylcobalamin yet (will be 2 weeks tomorrow) but I just wanted to make sure it was shipped and on its way to me?:-) I live in the USA (Colorado) so I know there are shipping delays due to COVID but am hoping it will be here soon!
I do have pernicious anemia (had all the tests and tested positive for both antibodies) and both my primary care doctor and naturopathic dr are supportive of me getting treatment and B12 injections. Right now, I’ve been doing self injections of methylcobalamin every 3 days (1 ml) but it has benzyl alcohol in it and I think I’m reacting to that (some rashes around my mouth/chin) and sinus allergies seem to be worse on those days I give myself an injection (started the B12 injections about 6-7 weeks ago). I am “sensitive” so I’m hoping that when your product arrives, things will be better and I’ll be giving myself more frequent smaller injections as suggested on your website. My naturopathic dr suggested every other day for now?
Thanks in advance for your time and assistance, much appreciated!
Liz
Regev,
I got the package in the mail. Thanks a million!
I wasn’t aware that the quantities of B12 were so small in the glass jar. It’s amazing to think that such a small amount does wonders to the body.
Before I start injecting, I wanted to ask you about your experience with drinking the Methylcobalamine. I have read contradictory information online and, if it works, for sure I would prefer this method.
Thanks!
Quedo atento, Sincerely,
Sergio
My husband is 45 yr old active man with Type 1 Diabetic, has Hashimotos thyroid, and Vitilligo. He has had symptoms of debilitating brain fog off and on for over 10 years. He recently received the COVID vaccine and developed severe brain fog, fatigue, tinnitus, shortness of breath, dizziness, heat and activity intolerance. These symptoms have persisted for 4 weeks since the vaccine. Dr ordered a B12 level at my request and it was 367, it was 399 back in 2016. I am very suspicious of pernicious anemia, however his primary will not order antibody testing because his lab numbers are “normal”. He is switching Drs which will take 2 months. In the mean time he has started Mercola B12 spray sublingual but I am not sure if he is able to absorb this way ?
Any guidance or advice is appreciated.
Thank You!
I first took 1000 mg every few days, I am now taking it once a week. That was my usual dose before the pandemic. Once a week is perfect for now. I’m still on my first bottle. I am so glad and grateful I found your website.
I finally surpassed my 90 days!!! I am much better than I was 90 days ago. The L Methylfolate was a great benefit! My joints are getting better everyday. The neuropathy in my hands was gone… or so I thought. I had to be treated for a urinary tract infection with keflex. This kicked up the neuropathy in my hands ! So frustrating!!!! At the 90 days I tried injecting methyl b 3 days/week. My body was fine with that until I took the Keflex. So I began injecting everyday again. My hands are almost normal again. I am thinking about injecting 3x/week as soon as my hands feel normal. My doctor ran blood work with the uti. She informed me to stop taking b12 pills as she said my b12 levels are off the charts! I asked her what the dangers of a high b12 level are? She said kidney failure is possible amongst other things. She never mentioned any other dangers? Of course she has no idea that I inject! The doctors here in Mississippi are only good for treating sore throat and a uti… and that’s only due to the fact that their computers tell them how to treat those! I will tell you this Regev… in January of 2021 I thought I was going to die! I may not be 100% yet but I no longer feel as though I am dying… I feel so much better! I am working on my digestion. I am taking L Glutamine, Lysine, L Methylfolate, and B6. It seems to be making a difference. I am determined to get my health back this year! I printed the diet from your website and find it extremely helpful!
I will continue to inject because there is NO WAY I can fall backwards!
Thanks for checking on me Regev. Honestly I would be in a very bad way if it was not for you. I am determined to continue moving forward!
What do you think of these COVID vaccines?.. I have not gotten the vaccine yet because my body has been trying to recover from this b12 deficiency. My doctors do not understand b12 deficiency so I really cannot have an intelligent conversation with them regarding if it is safe for me. Do you believe they are safe for all of us b12 deficient people? I feel as though here in the U.S. we the people are the “study”. I am just beginning to feel better and heal… the last thing that I want is to cause a setback due to a vaccine. I seem to be extremely sensitive to medications.
I pray all is well on your side of the world. I pray if you have family in Israel that they are safe and well*
My best… Angela
Hello! I am in the US do you guys ship here! I have been vegetarian for 20 years and expressing neurological symptoms of b12 def.
Hi, I found a local sauna that can give me B12 shots, but I checked their label and it has benzyl alcohol as a preservative. What’s the deal with this ingredient, is it dangerous? Thanks!
Hi Regev,
I have been injecting methylcobalamin .5 ml for 40 days. Pernicious anemia with neurological symptoms. I am experiencing improvement and the progress seems to be accelerating over the last week. Before that I was injecting cyanocobalamin and progressing so I can not really evaluate the methylcobalamin other than to know it is effective. Thank you.
My question today is do you know of anyone I could be treated by who understands pernicious anemia? I have not found anyone who is competent although I can find many qualified. I am not qualified or competent. I am willing to travel and have had both vaccinations. I live in New Hampshire.
Thanks again,
Michael
Hello, I recently started giving 2000mcg injection every other day for one month now and I feel more tired than usual. why is that? Do you know? does it take a while for it to work?
I am taking the shots and am noticing a significant reduction in inflammation. So thank you.
Hi, as I await arrival of the 3 months of B-12 kit from PA Relief, I wanted to ask – I have what seems to be optical neuropathy that has responded some to B-12 sublingual last 3 weeks, but not enough, given it’s 7 months duration, and I have neurological symptoms of pernicious anemia, very low intrinsic factor, and 167 last B-12 lab April 22. The hematologist prescribed 5 days and then every other day 5 more days of loading doses of B-12 cyanobalamin, which I won’t take but all they have injection in Georgia that I could find. Should I forget about the loading doses of B-12 and just go with the PA Relief 3 months daily injections of methylcobalamin? Or do I need to do ‘loading doses’ ? Thank you and best regards, Michael
I am now convinced Methylcobalamin is the B12 form for me. I am a smoker and I came across information that indicated smoking interferes with the absorption of B12. I am also doing much better and it happened fairly quickly at about 50 days of injecting Methylcobalamin. Thank you for your work.
In the TWW category. (Too Weird for Words), my saliva now has a different quality. It is less ‘sticky’. Whereas saliva has an effect on B12 absorption is it possible that measuring the saliva could be a test for B12 deficiency or pernicious anemia?
Hi Regev,
It’s really amazing what you’re doing here. I stumbled across your site after suffering some pretty bizarre symptoms, come to find out they we’re not all that bizarre to begin with.. Tingling legs and hands, fatigue for over a year without any understanding, horrible headaches past few months and a sense of falling (Hypnic jerks) as I would drift into dreamland at night.. I came to the conclusion of pernicious anemia as I have been anemic since 8 years old. Was given far too many antibiotics as a child and I’ve also committed to a vegan diet over the past few years which has not helped as I am learning as I go😅
Very much looking forward to trying this out as big pharma / western medicine doctors that I’ve seen have been of no help. I haven’t used your product yet but I have a feeling this is the answer I didn’t know I’ve needed for some time. Thank you for looking out for the people and making it at a fair price. Much love to you and yours and hopefully all is well during these times. 🙏
Best,
Kazem
I had my B12 levels tested and It came back over 1400. I do not supplement any B12 or take a multivitamin. I did however get a one time B12 shot three weeks ago due to fatigue. Would that still be in my blood system still and affect the test levels?
It’s going great. I just started injecting a week ago due to travel and getting the other supplies together, but it’s been easier than I expected it to be.
Hey there Regev
I don’t feel like much is happening to alleviate my B12 deficiency symptoms. I have some relief, and got that within days of starting the injections, but I feel like I am still very deficient and stagnant. I have been diagnosed with the MTHFR gene, and I know this contributes to added issues with my absorption of B12.
I do .30 injection per day, and I wondered if I should use more, or if it is wasting the B12? Just so you know, my urine is a normal color and there doesn’t seem to be any sign that I am excreting excess B12 (judging by the urine color)
Believe me, I know there may be other factors causing ongoing symptoms, and the symptoms I have mimic so many other health issues, but if you think it is worth bumping up the dosage please let me know
With that being said, I am addressing the plethora of symptoms, and awaiting some results and guidance from my holistic practitioners to sort things out.
So, any knowledge you can pass along would be so very much appreciated. I don’t expect you to “doctor” me LOL, just some friendly input.
All the best-
Lisa
Hello, I was diagnosed with PA years ago and have taken cynaocobalamin injections for 30 years. My new insurance, an HMO and new doctor will not prescribe B-12 injections for me. She did a blood test that came back with the number of 640 and now will not even discuss PA with me. She insists I don’t have it. What can I do? What questions and tests can I request for her to take me seriously? Please help me.
Thank you so much. I believe my husband is suffering from pernicious anemia and is also having major neuropathy. He recently learned he has diabetes, however I really think he is severely deficient or unable to absorb. I moved to a different state 6 months ago while he was finishing up his job. We are both in Idaho now and I asked him to at least try it for 90 days. I couldn’t figure out how I was going to get 3 months out of that vial but when I reordered I saw I should have received 3 vials. Life has been very very crazy busy with moving out of state and transporting our household. Sorry for being such an unorganized person and not realizing I did not receive 3. This means the world to me. I. Pretty healthy but also want to take for optimal health, so we will definitely be reordering. My DIL has crohns and I’m still praying they will open their minds and try this.
Best regards,
Mary
I’ve battled for years with several things. I’m a ovarian cancer stage 3C survivor of 28 years, six years ago I as diagnosed with
Chronic Idiopathic Urticaria + Angioedema.
-and-
Undifferentiated Connective-Tissue Disease
-and-
Bell’s Palsy
-and-
Vocal cord disfunction
-and-
Antiphosholipid Antibody Disorder
(Antiphospholipid syndrome)
Also, in 2006 I ruptured several disc in my lower cervical and had surgery for fusion. Two years ago the upper part of my cervical 2-4 had narrowed tremendously causing pain and problems with my dominant arm. I’m undergoing injections right now praying to ward off another surgery.
I’m very active with my family and watch my three grandkids four days a week. I’ve been also taking care of my 81 year old mom.
I’m hoping the B12 shots will help as not one of my doctors have offered nor agreed to give me one instead I feel like they just want to push pills to put a bandage on it.
Hi, thank you very much.
I got the order, and made the first solution – vial. I made a 2nd order from a USA company because I wasn’t sure when the PA Relief order would arrive,
and also a lipotropic b-complex. However, in doing the calculations, if I calculated correctly, the PA Relief is higher concentration of methyl B-12, in less solution,
which as for self-injection, which I have been doing, is more preferable imho. I have had some improvement with what has been a digital eye strain, feeling like
optical neuropathy ( hope not diabetic neuropathy) in left eye – I didn’t see an ophthalmologist. I did get an intrinsic factor test before ordering and saw the hematologist
who called what I have ‘classic anemia’ or ‘b-12 deficiency anemia. I was at 500 ml injections of the USA company’s methylcobalamin since around 13th –
in short, trying to use that up and go with the PA Relief methylcobalamin after that, maybe sooner, because I’ve had some feeling in the lower back – not sure if it
kidney related – or as I was diagnosed with arthritis there, what that is, it’s a different feeling I haven’t had before. I did seem to get some feeling back in my feet
when taking off socks and ‘feeling’ sunshine on them after starting of self-injections. I am doing the diet as shown on PA Relief. The injections of methyl B-12
from the USA company (Vitaminquick) are at only 500 ml, which is also what the Georgian hematologist ordered – though I’m planning to keep on higher dose
daily injections for hoping to see what or how much nerve regeneration can happen over 6 months, etc. and not wanting to ever fall into deficiency again, obviously
can’t or shouldn’t risk that given the neuropathy, and other severe symptoms I’ve had going to back to age 30. My grandfather had pernicious anemia. But I only
found out about that 2nd week of May 2021. So I’m not sure if I have something with just lower back where I normally use infrared treatment daily, but when I don’t
if it’s that, or the injections, or what that is yet, but I seem to notice it for sure if I’m not doing the infrared treatments daily.
By the way, the order from PA Relief DID arrive within the time stated, and thank you for that, with no problems. Because of my left eye, I panicked perhaps,
and made that 2nd order from Vitaminquick, as a backup – as it came DHL Express, and not sure then how things would work with the post system here. So actually
both PA Relief and VitaminQuick arrived in the same two-day period of time.
In short, yes, I’ve started the self daily injections of B-12, I’m trying to ‘use up’ the Vitaminquick stuff and get to the PA Relief better-concentrated injections –
due to the amount of neuropathy that I have had, before finding out about pernicious anemia on myself, it was difficult to discern permanent myofascial and some
back, spine damage from a late 2009 65 mph car accident hit from behind, and the horrible symptoms of pernicious anemia which I’ve only been learning about
for about a month now in terms of reading and realizing that. I have for example also ‘capgras mania’ at age 30 – 34 – 5 months total of hospitalizations in those
years…. onset at age 30. delusion and Capgras’ syndrome – https://pubmed.ncbi.nlm.nih.gov/15029091/ > This is a very specific kind of mania,
and I had it…. but what I was diagnosed with, there is no medical lab tests for that I’m aware of, now I wonder how much if and was ‘pernicious anemia’.
I’ve sent you the CBC the hematologist here ordered, I didn’t go back to her because she wanted the scoping of the stomach and I haven’t
chosen to do that yet. I’m hoping the blood tests will get back to normal or better in some weeks with these methyl B-12 injections, and I hope to plan
to fly sometime after that back to the United States where I haven’t been for two years due to the pandemic.
So there are some changes I feel, regarding the lower back not sure if that’s kidney’s or arthritic condition diagnosed by spine specialist (car accident related likely)
after cat scan or mir there back in late 2018, or if it’s related to the b-complex – lipotropic injection, – or something else, as I mentioned if I don’t do the infrared daily
20 minutes there I feel something, but this is a new kind of feeling. I do notice less to little nerve pain in legs and spine already…. many mornings i’d wake up
before doing injections and the sublingual b-12 since May 10 or so, with tingling numbness in spine…. that has seemed to go away.
So I’m open for suggestions, I’ll keep injection the B12 and doing the diet and get the CBC and B12 lab test again sometime in the next weeks ahead.
Thank you, and best regards,
Michael Vanderpool – labs attached.
P.S. I think we can say for sure around 12th or 13th I was taking the 500 ml per day injections daily, so it’s not been that long, and after finishing up that, I plan to – if not sooner
be on the daily PA relief b-12 injections. I got some of the lipotropic b complex also because of the medical studies on some of the b-vitamins helping with the nerve regeneration
also. However, I’ve read where that should maybe only be used alternating days with B-12 injections.
Michael
Hello,
I just had my B12 tested and it came back at 400, folate 22.4 . I just came across your site. In December I had major headaches for a week, tinnitus, balance issues, now I’m having neurological tingling in my lower legs and arms and I’m wondering if it might be due to a low B 12 serum. I am also having shortness of breath which no one seems to be able to tell me why . I don’t know if this is a symptom or not of low B 12. What if you think? Thanks
I received my first B12 bottle from you this morning and I am so excited to start it, I was going around the house thanking God. My reason is not as heartbreaking as most of the family of people that order from you, I live with no energy, I’m literally so tired all the time and I recently learned about the B12 and what it can do for me. You are absolutely right about all that anyone wants to give you is that man made stuff that from what I read it terrible for you and probably doesn’t work for most people anyway. It’s a sad truth that that pharma and most Dr’s do not want to help you. God bless you for what you are doing and I will let you know how it goes for me and my sister is the same as I am with the lack of energy in a big way and we will probably be buying again soon.
Hi there!
I JUST finished my first bottle. I am not using it everyday. My homeopathic Doc before I moved and in the “before times” had me injecting once a week except when I first started. It was every other day for the first week. I inject on Fridays.
It’s amazing the difference in my fatigue level. Most days I don’t need a nap. The tingling is gone. Memory issues are improved, concentration is better as well. So, it’s working and I am thrilled. I see a new Doc at the end of the month where I’m sure I’ll get blood work. Regular Docs here in the US do not lean towards B12 for pernicious Anemia. I am so glad I found you to keep my dignity intact.
Thank you
Annette
I received the B12 shipment. I’m actually dealing with a bunch of health related issues (GI related) and I’m not entirely sure if my B12 deficiency is the cause of all of it or the GI issues are causing other deficiencies. So I’m in the middle of a bunch of followup GI testing. I’m in a pretty rough spot at the moment, so I’ve decided to hold off on new changes until I get the test results back. I currently inject cyanocobalamin weekly. If there is nothing there to worry about, and I stabilize a bit more, then I will start experimenting with the methylcobalamin.
If you have any stories of people who had some pretty bad GI issues at the start of their B12 deficiency recovery (I’m 2 months in), and recovered with time, that would be great to hear.
Cheers,
Chris
Thank you. The order arrived safely and I’m very happy with it. I did my first injection almost 2 weeks ago, and I feel great. Thank you for this option, to not have to argue with a doctor. Thank you thank you. I have gotten injections for almost 2 years, but I have to fight for it every month. The difference is astounding and this means I have it, without needing to pay to prove it. This is a life changer for me. I was worried it wasn’t real, but I feel the difference! Just thank you, from the bottom of my heart. A simple vitamin shouldn’t be so hard to get.
Hi Regrev,
I am a month into trying your Methyl B12 and have seen some improvement, particularly with numbness and aches.
My question is about managing my expectations for the future.
Is treatment with Methyl B12 my best chance at REVERSING neurological damage/symptoms that have already progressed? Could you offer me any further tips?
Sadly, it’s increasingly clear to me that the NHS (UK) has failed me with the time it took to achieve deficiency diagnosis (2+ years) and then infrequently poor / even refusal of treatment for a further 2 years.
As a result symptoms that appear to be neurological in nature have progressed, to name a few – a sense of detachment, balance, breathing problems, concentration and back ache.
I am 33 years old, a former fitness trainer with a healthy lifestyle but I am at my wits end with what else to do. Any further feedback you can offer would be greatly appreciated. I will be continuing with your product.
Kind Regards
Dear Mr. Elya,
It is time for me to reorder the B-12. You will see that today. I have been having to take the protocol slow as I have about 12 vitamin and mineral deficiencies, to my shock.
These past 2 weeks I have felt real energy and it makes me hopeful I can turn my life around.
My vitamin and mineral deficiencies began at the age of 7 and now I am 73. My mother was a pediatric nurse for a pediatrician so at least there was recognition of deficiencies. I became a biochemist and health and nutrition are my personal interests. A few years ago, genetic testing showed I am Ashkenazi on both sides, another surprise.
Regards,
Norma
I received my order and I have been injecting. I don’t have PA but I had colon cancer and the resection took out the last foot of my small intestine and 1/3 of my large intestine. I have had B12 deficiencies ever since. My doctor would order the cheap B12 shots and for some reason I would feel tired the next day. I don’t think she believed me. So I have been using your B12 very successfully and feel great. Thank you so much!
Doris
Hi Regev,
I’m so excited to try B12 injections and glad you sell the better, more absorbable, pure form (methylcobalamin) of B12. I’m using it for more energy and mental clarity. As a health advisor for the Life Extension Foundation for over 15 years I know the importance of B12 – especially for people over 50.
Not too long after I turned 60 I noticed I was starting to feel weak and tired, had a hard time sleeping, had headaches all the time, low appetite (which is unusual for me as I’ve always had a strong appetite), have heart palpitations, felt light-headed at times, and just seem to have lost my zest to go out and do things.
So I tried to convince my doctor to give me B12 shots, but she wouldn’t. Then I started taking sublingual methylcobalamin supplements and noticed (after a week of triple dosing!!) I started to feel a better, and all of those symptoms listed above seemed to improve a bit.
Now I know I need B12 to really feel good.
But finding pharm-grade, absorbable, methylcobalamin B12 shots without a prescription was difficult until I found your organization. Now I can’t wait to try them!
Thanks so much,
Linda
I’ve been injecting daily and love the energy I’ve gotten. I will definitely be ordering next months supply when able.
Thank you Regev,
You may be the only person in the world offering such a lifesaving service!
Here’s my story. I’m 57 years old and in general thin, and healthy and have a fairly balanced diet, although I would frequently have coffee and pastries for breakfast, and sweet deserts and/or alcohol with meals. Around 8 months ago I started developing sporadic diarrhea that appeared to be related to consumption of caffeine and/or sugar and/or alcohol. I couldn’t exactly pin it down to any particular food or drink since the diarrhea wouldn’t always happen. Then around the Thanksgiving and Christmas holidays I overate on sweets and alcohol and my body entered a deteriorating spiral that I couldn’t get out of. My diarrhea turned into severe constipation(like 1 bowel movement a week) and I started rapidly losing weight no matter what I ate. Of course my eating was limited because my abdomen was so bloated due to the severe constipation. I also developed tingling in the hands and feet, a weird feeling when swallowing, a feeling of prominent heartbeat, and a burning sensation throughout my back and abdomen.
My primary care doctor ordered innumerable blood tests including Vitamin B12 levels which were normal.
I scheduled doctors appointments with multiple specialists, but they were booked out for months so I had to do something on my own. I researched on the internet and came to believe that I was having gastrointestinal related Mast Cell activation syndrome, so I radically changed my diet to a low histamine diet. At this point I had lost 20% of my body weight and I looked like a skeleton. The diet did stabilize my weight and my bowel movements began to normalize after about two months. My other symptoms that I previously described waxed and waned throughout this time, but then about 4 months ago my gait suddenly got abnormal. I had trouble walking. If I was walking my dog and I turned my head to the side my legs didn’t know how to move and I would stumble. I researched gait disturbance on the internet and Vitamin B12 deficiency was one of the possible causes. Additionally I found out that another weird specific symptom of B12 deficiency was tongue swelling and pain. I remembered that I had been awakened from sleep twice over this time period with pain in the right side of my tongue with a swollen feeling in the tongue. It would only last about a minute and I would fall back asleep. That was enough for me. I figured I had a B12 deficiency. I went to a neurologist who said he could not prescribe B12 injections because my B12 lab test was normal. (He seemed like he wanted to but he was under the rules and control of his hospital system and could not order or prescribe everything he wanted. Unfortunately I think a lot of doctors in the US are now just rule-following employees. )He did order some more tests and it turned out I was deficient in copper and zinc. He thought my neurological symptoms could be due to the copper deficiency so he prescribed copper supplements which I took but my gait disorder did not improve. On my own I bought oral B12 tablets and started taking it 4 times per day in giant doses, around 40,000 mcg per day. My gait disorder stabilized but did not go away, and in addition I started developing memory problems, like I could not remember peoples names that I had known for years.
I did more research on the internet on B12 deficiency and finally found this website. It looked too good to be true( I am naturally skeptical ), and I was worried it could actually be a scam, but I was desperate so I ordered 6 months worth of your B12 powder. I followed your injection instructions to the letter. (As an aside, on this forum I’ve read that some people have had trouble finding syringes and saline in the correct size. I got my supplies at http://www.healthykin.com : McKesson Insulin Syringes with Needles-31G, 5/16”, .3ml, box of 100, and BD PosiFlush Pre-filled Saline Syringe-10ml, box of 30, and McKesson Alcohol Prep Pads box of 200.)
I have been injecting now once a day in the morning precisely following your injection instructions. I have also included oral folate supplements, probiotics and have expanded my diet(but still excluding caffeine, alcohol and sugar). I am happy to say that your B12 works! My neurological symptoms have finally completely resolved after 2 ½ months of injecting. I gained back my weight and my constipation is gone.
I also finally got my GI workup which included endoscopy/colonoscopy and biopsies and everything was normal. No atrophic gastritis. No celiac disease. The gastroenterologist did not want to order antibody tests for parietal cell or intrinsic factor but I pleaded with him so he ordered the test for intrinsic factor antibodies. Ironically my B12 level was now so high that it made the antibody test unreliable. So I basically have no diagnosis as far as the medical profession is concerned.
I continued to research diet disorders and B12 deficiency and found this link( https://articles.mercola.com/sites/articles/archive/2021/07/24/vitamin-b12-deficiency-symptoms.aspx?ui=8404abaf66479c34b3f633ffe5bcfff758768094a09c1387c46dbbffc005fb05&sd=20140821&cid_source=dnl&cid_medium=email&cid_content=art2HL&cid=20210724_HL2&mid=DM944496&rid=1216758403 ), which convinced me that my entire problem was self-induced by daily consumption of sugar/caffeine/alcohol, which adversely altered my intestines and intestinal bacteria resulting in B12 deficiency, and other vitamin deficiencies. I’m still not sure if I have parietal cell or intrinsic factor antibodies and will require B12 injections for the rest of my life, but I will have to figure that out myself over time. I know other people on this website may have other causes for their B12 problem, but I want you to know that Regev’s B12 powder AND his comprehensive information and instructions work! Thank you again Regev.